Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina
A new psammaplysin derivative, ceratinadin G (1), was obtained from the Okinawan marine sponge Pseudoceratina sp., and the gross structure was clarified through spectroscopic and spectrometric analyses. The absolute configuration of compound 1 was established by comparing its NMR and ECD data with t...
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| Language: | English |
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Beilstein-Institut
2024-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.20.267 |
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| author | Shin-ichiro Kurimoto Kouta Inoue Taito Ohno Takaaki Kubota |
| author_facet | Shin-ichiro Kurimoto Kouta Inoue Taito Ohno Takaaki Kubota |
| author_sort | Shin-ichiro Kurimoto |
| collection | DOAJ |
| description | A new psammaplysin derivative, ceratinadin G (1), was obtained from the Okinawan marine sponge Pseudoceratina sp., and the gross structure was clarified through spectroscopic and spectrometric analyses. The absolute configuration of compound 1 was established by comparing its NMR and ECD data with those of the known psammaplysin derivative, psammaplysin F (2). Ceratinadin G (1) is a rare nitrile containing a cyano group as aminoacetonitrile, and is the first psammaplysin derivative possessing a cyano group. In vitro assays indicated that compound 1 displayed moderate cytotoxicity against L1210 murine leukemia cells and KB epidermoid carcinoma cells. |
| format | Article |
| id | doaj-art-8f4ee4d362e643b9a24974b127597e61 |
| institution | Kabale University |
| issn | 1860-5397 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-8f4ee4d362e643b9a24974b127597e612025-01-06T12:27:36ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972024-12-012013215322010.3762/bjoc.20.2671860-5397-20-267Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus PseudoceratinaShin-ichiro Kurimoto0Kouta Inoue1Taito Ohno2Takaaki Kubota3Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan A new psammaplysin derivative, ceratinadin G (1), was obtained from the Okinawan marine sponge Pseudoceratina sp., and the gross structure was clarified through spectroscopic and spectrometric analyses. The absolute configuration of compound 1 was established by comparing its NMR and ECD data with those of the known psammaplysin derivative, psammaplysin F (2). Ceratinadin G (1) is a rare nitrile containing a cyano group as aminoacetonitrile, and is the first psammaplysin derivative possessing a cyano group. In vitro assays indicated that compound 1 displayed moderate cytotoxicity against L1210 murine leukemia cells and KB epidermoid carcinoma cells.https://doi.org/10.3762/bjoc.20.267ceratinadincytotoxicitymarine spongepsammaplysinpseudoceratina sp. |
| spellingShingle | Shin-ichiro Kurimoto Kouta Inoue Taito Ohno Takaaki Kubota Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina Beilstein Journal of Organic Chemistry ceratinadin cytotoxicity marine sponge psammaplysin pseudoceratina sp. |
| title | Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina |
| title_full | Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina |
| title_fullStr | Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina |
| title_full_unstemmed | Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina |
| title_short | Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus Pseudoceratina |
| title_sort | ceratinadin g a new psammaplysin derivative possessing a cyano group from a sponge of the genus pseudoceratina |
| topic | ceratinadin cytotoxicity marine sponge psammaplysin pseudoceratina sp. |
| url | https://doi.org/10.3762/bjoc.20.267 |
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