A molecular mechanism for eflornithine resistance in African trypanosomes.
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the protozoan parasite Trypanosoma brucei. Eflornithine is used as a first line treatment for human African trypanosomiasis, but there is a risk that resistance could thwart its use...
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| Main Authors: | Isabel M Vincent, Darren Creek, David G Watson, Mohammed A Kamleh, Debra J Woods, Pui Ee Wong, Richard J S Burchmore, Michael P Barrett |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-11-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001204&type=printable |
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