Prevalence and Risk Factors for Atherosclerotic Cardiovascular Disease in 7704 Individuals: An Analysis from the Greek Registry for the Prevalence of Familial Hypercholesterolemia (GRegistry-FH)

Prevalence and Risk Factors for Atherosclerotic Cardiovascular Disease in 7704 Individuals: An Analysis from the Greek Registry for the Prevalence of Familial Hypercholesterolemia (GRegistry-FH)

The intention of this study was to profile the cohort from the Greek Registry for the prevalence of Familial Hypercholesterolemia (GRegistry-FH) by estimating the prevalence of coronary artery disease (CAD), myocardial infarction (MI), stroke, dyslipidemia, arterial hypertension, diabetes mellitus (...

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Main Authors: Genovefa Kolovou, Stamatis Makrygiannis, Christina Marvaki, Niki Pavlatou, Katerina Anagnostopoulou, Vasiliki Giannakopoulou, Georgios Goumas, Petros Kalogeropoulos, Vana Kolovou, Sotiria Limberi, Despina Perrea, Anastasios Tzenalis, Zeimpek Emre, Edison Jahaj, Zoi Kasiara, Ilias Giannakoulis, Ioannis Tsolakoglou, Olga Kadda, Nikolaos Tsaloukidis, Rafailia Koulaxidou, Aikaterini Marvaki, Stefanos Foussas, Andreas Melidonis, Giannis Hoursalas, Charalambos Vlachopoulos, Niki Katsiki, Haralampos Milionis, Evaggelos Liberopoulos, Helen Bilianou
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
ASCVD (atherosclerotic cardiovascular disease)
dyslipidemia
hypertension
prevalence
prevention
registry
Online Access:https://www.mdpi.com/2308-3425/11/12/411
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Summary:The intention of this study was to profile the cohort from the Greek Registry for the prevalence of Familial Hypercholesterolemia (GRegistry-FH) by estimating the prevalence of coronary artery disease (CAD), myocardial infarction (MI), stroke, dyslipidemia, arterial hypertension, diabetes mellitus (DM), pre-DM, smoking, abnormal thyroid function (ATF), and lipid values. The GRegistry-FH is a prospective study involving door-to-door interviews conducted by trained interviewers. Overall, 7704 individuals aged ≥18 years, randomly selected from all the regions of Greece, participated. The prevalence of atherosclerotic cardiovascular disease (ASCVD) was 13.9% (CAD 6%, MI 3.2%, stroke 4.7%). Treated hypercholesterolemia was present in 20.1%, arterial hypertension in 24%, and DM in 11.3% individuals (25.5% had pre-DM). The prevalence of smoking was 37.9% (29% current) and the prevalence of ATF was 13.1% (hypothyroidism 11.3%). A family history of ASCVD was reported by 60.5% (CAD 32.2%, stroke 28.3%). The mean (SD) lipid values in mg/dL were as follows: total cholesterol of 201.8 (41.5), low-density lipoprotein cholesterol of 126.3 (30.1), high-density lipoprotein cholesterol of 51.9 (12.5), and triglycerides of 135.9 (64.7). The GRegistry-FH highlights the significant prevalence of ASCVD and its risk factors among Greek adults, indicating a pressing need for early detection and management strategies to mitigate ASCVD burden. This nationwide registry serves as a crucial tool for guiding public health policies and personalized preventive measures (NCT03140605).
ISSN:2308-3425

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