Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study
Abstract Background In China many respiratory pathogens stayed low activities amid the COVID-19 pandemic due to strict measures and controls. We here aimed to study the epidemiological and clinical characteristics of pediatric inpatients with Mycoplasma pneumoniae pneumonia (MPP) after the mandatory...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-10370-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559825352228864 |
|---|---|
| author | Yuqian Zhang Chenglei Su Yang Zhang Shuo Ding Xianliang Yan Jianguo Zhang Zhimin Tao |
| author_facet | Yuqian Zhang Chenglei Su Yang Zhang Shuo Ding Xianliang Yan Jianguo Zhang Zhimin Tao |
| author_sort | Yuqian Zhang |
| collection | DOAJ |
| description | Abstract Background In China many respiratory pathogens stayed low activities amid the COVID-19 pandemic due to strict measures and controls. We here aimed to study the epidemiological and clinical characteristics of pediatric inpatients with Mycoplasma pneumoniae pneumonia (MPP) after the mandatory COVID-19 restrictions were lifted, in comparison to those before the COVID-19 pandemic. Methods We here included 4,296 pediatric patients with MPP, hospitalized by two medical centers in Jiangsu Province, China, from January 2015 to March 2024. Patients were divided into the pre-COVID (n = 1,662) and post-COVID (n = 2,634) groups. Their baseline characteristics, laboratory test results and radiological patterns were separately assessed and compared between the two groups to determine the substantial changes in the disease profile of MPP after the COVID-19 pandemic. Results Epidemiological results suggested a higher annual incidence of MPP after the COVID-19 pandemic when the outbreak reached a peak in October, two months delayed in seasonality compared to that in the pre-COVID era. For pediatric patients with MPP, there was no difference in their median ages, gender ratios, and severe case percentages between the two groups, where most patients were younger than 14 years old. With significance, the post-COVID group had more occurrences of cough and expectoration and higher incidences of influenza A/B virus (IAV/IBV) co-infection than the pre-COVID group. Many hematological parameters and radiological features between the two groups displayed alteration, but comparatively there demonstrated no worsened severity in hospitalized children with MPP after COVID-19 pandemic. Concurrently, the post-COVID group was administered with fewer antibiotics but more corticosteroids for effective treatment than the pre-COVID group. Conclusion Through the COVID-19 pandemic, the epidemiological and clinical characteristics of pediatric patients with MPP differed, but there was no evident change in the disease severity. After the COVID-19 pandemic, the increased incidence of IAV/IBV co-infection may contribute to the differences in clinical symptoms and hematological profiles, while the adding usage of corticosteroids might treat more effectively. |
| format | Article |
| id | doaj-art-8f20c579d63548179106c6a9303c66e0 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-8f20c579d63548179106c6a9303c66e02025-01-05T12:09:43ZengBMCBMC Infectious Diseases1471-23342025-01-0125111310.1186/s12879-024-10370-8Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter studyYuqian Zhang0Chenglei Su1Yang Zhang2Shuo Ding3Xianliang Yan4Jianguo Zhang5Zhimin Tao6Department of Emergency Medicine, Affiliated Hospital of Jiangsu UniversityDepartment of Emergency Medicine, Affiliated Hospital of Xuzhou Medical UniversityDepartment of Emergency Medicine, Suining County People’s HospitalDepartment of Emergency Medicine, Fengxian County People’s HospitalDepartment of Emergency Medicine, Affiliated Hospital of Xuzhou Medical UniversityDepartment of Emergency Medicine, Affiliated Hospital of Jiangsu UniversityDepartment of Emergency Medicine, Affiliated Hospital of Jiangsu UniversityAbstract Background In China many respiratory pathogens stayed low activities amid the COVID-19 pandemic due to strict measures and controls. We here aimed to study the epidemiological and clinical characteristics of pediatric inpatients with Mycoplasma pneumoniae pneumonia (MPP) after the mandatory COVID-19 restrictions were lifted, in comparison to those before the COVID-19 pandemic. Methods We here included 4,296 pediatric patients with MPP, hospitalized by two medical centers in Jiangsu Province, China, from January 2015 to March 2024. Patients were divided into the pre-COVID (n = 1,662) and post-COVID (n = 2,634) groups. Their baseline characteristics, laboratory test results and radiological patterns were separately assessed and compared between the two groups to determine the substantial changes in the disease profile of MPP after the COVID-19 pandemic. Results Epidemiological results suggested a higher annual incidence of MPP after the COVID-19 pandemic when the outbreak reached a peak in October, two months delayed in seasonality compared to that in the pre-COVID era. For pediatric patients with MPP, there was no difference in their median ages, gender ratios, and severe case percentages between the two groups, where most patients were younger than 14 years old. With significance, the post-COVID group had more occurrences of cough and expectoration and higher incidences of influenza A/B virus (IAV/IBV) co-infection than the pre-COVID group. Many hematological parameters and radiological features between the two groups displayed alteration, but comparatively there demonstrated no worsened severity in hospitalized children with MPP after COVID-19 pandemic. Concurrently, the post-COVID group was administered with fewer antibiotics but more corticosteroids for effective treatment than the pre-COVID group. Conclusion Through the COVID-19 pandemic, the epidemiological and clinical characteristics of pediatric patients with MPP differed, but there was no evident change in the disease severity. After the COVID-19 pandemic, the increased incidence of IAV/IBV co-infection may contribute to the differences in clinical symptoms and hematological profiles, while the adding usage of corticosteroids might treat more effectively.https://doi.org/10.1186/s12879-024-10370-8Mycoplasma pneumoniaePneumoniaPediatric hospitalizationCOVID-19 pandemicMacrolide resistance |
| spellingShingle | Yuqian Zhang Chenglei Su Yang Zhang Shuo Ding Xianliang Yan Jianguo Zhang Zhimin Tao Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study BMC Infectious Diseases Mycoplasma pneumoniae Pneumonia Pediatric hospitalization COVID-19 pandemic Macrolide resistance |
| title | Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study |
| title_full | Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study |
| title_fullStr | Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study |
| title_full_unstemmed | Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study |
| title_short | Epidemiological and clinical characteristics of hospitalized pediatric patients with Mycoplasma pneumoniae pneumonia before and after the COVID-19 pandemic in China: a retrospective multicenter study |
| title_sort | epidemiological and clinical characteristics of hospitalized pediatric patients with mycoplasma pneumoniae pneumonia before and after the covid 19 pandemic in china a retrospective multicenter study |
| topic | Mycoplasma pneumoniae Pneumonia Pediatric hospitalization COVID-19 pandemic Macrolide resistance |
| url | https://doi.org/10.1186/s12879-024-10370-8 |
| work_keys_str_mv | AT yuqianzhang epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy AT chengleisu epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy AT yangzhang epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy AT shuoding epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy AT xianliangyan epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy AT jianguozhang epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy AT zhimintao epidemiologicalandclinicalcharacteristicsofhospitalizedpediatricpatientswithmycoplasmapneumoniaepneumoniabeforeandafterthecovid19pandemicinchinaaretrospectivemulticenterstudy |