Factors influencing glycocalyx degradation: a narrative review
The glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx are not fully elaborated. This review summari...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490395/full |
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| author | Jing Wang Lan Ma Yu Fang Tengteng Ye Hongbo Li Peng Lan |
| author_facet | Jing Wang Lan Ma Yu Fang Tengteng Ye Hongbo Li Peng Lan |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | The glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx are not fully elaborated. This review summarizes factors leading to the reduction of the glycocalyx in detail, including inflammatory factors, ischemia-reperfusion, oxidative stress, lipids, glucose, high sodium, female sex hormones and others. Additionally, the mechanisms underlying its degradation are discussed. To better prevent and treat related diseases induced by glycocalyx degradation, it is a meaningful measure to avoid these factors. |
| format | Article |
| id | doaj-art-8f1e3ff5ded0458e90aaf3489c148b66 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8f1e3ff5ded0458e90aaf3489c148b662025-01-16T05:10:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14903951490395Factors influencing glycocalyx degradation: a narrative reviewJing Wang0Lan Ma1Yu Fang2Tengteng Ye3Hongbo Li4Peng Lan5Department of Cardiology, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Neurology, Wenzhou Traditional Chinese Medicine (TCM) Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang, ChinaDepartment of Cardiology, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Cardiology, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Cardiology, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi, ChinaDepartment of Cardiology, Nanning Hospital of Traditional Chinese Medicine, Nanning, Guangxi, ChinaThe glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx are not fully elaborated. This review summarizes factors leading to the reduction of the glycocalyx in detail, including inflammatory factors, ischemia-reperfusion, oxidative stress, lipids, glucose, high sodium, female sex hormones and others. Additionally, the mechanisms underlying its degradation are discussed. To better prevent and treat related diseases induced by glycocalyx degradation, it is a meaningful measure to avoid these factors.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490395/fullcell membrane structuresendotheliuminflammationreviewglycocalyx |
| spellingShingle | Jing Wang Lan Ma Yu Fang Tengteng Ye Hongbo Li Peng Lan Factors influencing glycocalyx degradation: a narrative review Frontiers in Immunology cell membrane structures endothelium inflammation review glycocalyx |
| title | Factors influencing glycocalyx degradation: a narrative review |
| title_full | Factors influencing glycocalyx degradation: a narrative review |
| title_fullStr | Factors influencing glycocalyx degradation: a narrative review |
| title_full_unstemmed | Factors influencing glycocalyx degradation: a narrative review |
| title_short | Factors influencing glycocalyx degradation: a narrative review |
| title_sort | factors influencing glycocalyx degradation a narrative review |
| topic | cell membrane structures endothelium inflammation review glycocalyx |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490395/full |
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