Modulated Alpha Power as a Predictor of Tinnitus Alleviation
Background: Pain associated with subjective tinnitus is known to be alleviated by treatments using a repetitive transcranial magnetic stimulation (rTMS). However, the mechanisms underneath are still on debate. We investigated the mechanism of tinnitus alleviation using time–frequency analyses. Me...
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| Format: | Article |
| Language: | English |
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AVES
2024-09-01
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| Series: | Journal of International Advanced Otology |
| Online Access: | https://www.advancedotology.org/en/modulated-alpha-power-as-a-predictor-of-tinnitus-alleviation-131947 |
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| _version_ | 1841524365185777664 |
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| author | Tae-Soo Noh Moo Kyun Park Seung-Ha Oh Jun Ho Lee Myung-Whan Suh |
| author_facet | Tae-Soo Noh Moo Kyun Park Seung-Ha Oh Jun Ho Lee Myung-Whan Suh |
| author_sort | Tae-Soo Noh |
| collection | DOAJ |
| description | Background: Pain associated with subjective tinnitus is known to be alleviated by treatments using a repetitive transcranial magnetic stimulation (rTMS). However, the mechanisms underneath are still on debate. We investigated the mechanism of tinnitus alleviation using time–frequency analyses.
Methods: Twenty-four patients were randomly assigned to the dual-site stimulation group (temporal and frontal stimulation, TF), singlesite stimulation group (temporal stimulation, T), or sham stimulation group. An age-matched control group was also included (n = 12). Electroencephalography (EEG) was recorded and patient data were analyzed before and after treatment.
Results: A frontal increase in EEG power was observed in the alpha (8-12 Hz) frequency band domain after treatment; this increase was most pronounced in the TF group, followed by the T group. The TF and T groups showed increased alpha power in the fronto-central channels only in the silent period between paired-pulse tones. The TF and T groups showed decreases in alpha power in the temporal region, particularly in the neural response to the first of the paired-pulse tones. The difference in tinnitus handicap index between pre- and post-treatment was positively correlated with the alpha power of the silent period in the frontal and fronto-central channels.
Conclusion: Dual-site stimulation showed the greatest alleviation of tinnitus-related discomfort, followed by single-site stimulation. Additionally, the modulation of alpha power was prominent in the active stimulation groups. Low frequency rTMS can alleviate tinnitus by increasing alpha band power and reducing hyperactivity. |
| format | Article |
| id | doaj-art-8f151d24da0d46fa83f4944ba13d992e |
| institution | Kabale University |
| issn | 2148-3817 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | AVES |
| record_format | Article |
| series | Journal of International Advanced Otology |
| spelling | doaj-art-8f151d24da0d46fa83f4944ba13d992e2025-02-03T07:15:03ZengAVESJournal of International Advanced Otology2148-38172024-09-0120539740410.5152/iao.2024.231051Modulated Alpha Power as a Predictor of Tinnitus AlleviationTae-Soo Noh0 Moo Kyun Park1Seung-Ha Oh2Jun Ho Lee3Myung-Whan Suh4Sensory Organ Research Institute, Medical Research Center, Seoul National University, Seoul, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, KoreaBackground: Pain associated with subjective tinnitus is known to be alleviated by treatments using a repetitive transcranial magnetic stimulation (rTMS). However, the mechanisms underneath are still on debate. We investigated the mechanism of tinnitus alleviation using time–frequency analyses. Methods: Twenty-four patients were randomly assigned to the dual-site stimulation group (temporal and frontal stimulation, TF), singlesite stimulation group (temporal stimulation, T), or sham stimulation group. An age-matched control group was also included (n = 12). Electroencephalography (EEG) was recorded and patient data were analyzed before and after treatment. Results: A frontal increase in EEG power was observed in the alpha (8-12 Hz) frequency band domain after treatment; this increase was most pronounced in the TF group, followed by the T group. The TF and T groups showed increased alpha power in the fronto-central channels only in the silent period between paired-pulse tones. The TF and T groups showed decreases in alpha power in the temporal region, particularly in the neural response to the first of the paired-pulse tones. The difference in tinnitus handicap index between pre- and post-treatment was positively correlated with the alpha power of the silent period in the frontal and fronto-central channels. Conclusion: Dual-site stimulation showed the greatest alleviation of tinnitus-related discomfort, followed by single-site stimulation. Additionally, the modulation of alpha power was prominent in the active stimulation groups. Low frequency rTMS can alleviate tinnitus by increasing alpha band power and reducing hyperactivity.https://www.advancedotology.org/en/modulated-alpha-power-as-a-predictor-of-tinnitus-alleviation-131947 |
| spellingShingle | Tae-Soo Noh Moo Kyun Park Seung-Ha Oh Jun Ho Lee Myung-Whan Suh Modulated Alpha Power as a Predictor of Tinnitus Alleviation Journal of International Advanced Otology |
| title | Modulated Alpha Power as a Predictor of Tinnitus Alleviation |
| title_full | Modulated Alpha Power as a Predictor of Tinnitus Alleviation |
| title_fullStr | Modulated Alpha Power as a Predictor of Tinnitus Alleviation |
| title_full_unstemmed | Modulated Alpha Power as a Predictor of Tinnitus Alleviation |
| title_short | Modulated Alpha Power as a Predictor of Tinnitus Alleviation |
| title_sort | modulated alpha power as a predictor of tinnitus alleviation |
| url | https://www.advancedotology.org/en/modulated-alpha-power-as-a-predictor-of-tinnitus-alleviation-131947 |
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