A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact
Objectives: To systematically review risk factors for patient-reported arm symptoms (AS) in breast cancer (BC), considering radiotherapy (RT) impact, using the EORTC QLQ-BR23 questionnaire (BR23). Methods: PubMed, Embase, Cochrane Library, MEDLINE, and Web of Science were searched using the keywords...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001437 |
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| author | Yuqin Liang Yuedan Zhou Ruud Houben Karolien Verhoeven Sofia Rivera Liesbeth J. Boersma |
| author_facet | Yuqin Liang Yuedan Zhou Ruud Houben Karolien Verhoeven Sofia Rivera Liesbeth J. Boersma |
| author_sort | Yuqin Liang |
| collection | DOAJ |
| description | Objectives: To systematically review risk factors for patient-reported arm symptoms (AS) in breast cancer (BC), considering radiotherapy (RT) impact, using the EORTC QLQ-BR23 questionnaire (BR23). Methods: PubMed, Embase, Cochrane Library, MEDLINE, and Web of Science were searched using the keywords ''breast neoplasms'', ''radiotherapy'', and ''BR23'' up to March 5th, 2024. Inclusion criteria: both univariate and multivariate analyses. Exclusion criteria: pregnancy, recurrence, distant metastasis BC, reirradiation, or lack of RT. The risk of bias of included papers was assessed using the Critical Appraisal Skills Program (CASP) checklist. Descriptive and meta-analyses were conducted using risk ratio (RR) or standardized mean difference (SMD) with 95 % confidence intervals (CI) as effect measures. A random-effects model was applied if I2 > 50 %. Results: Eighteen out of 734 studies were included, with sample sizes ranging from 172 to 2208. Commonly reported risk factors included axillary lymph node dissection (ALND), mastectomy, chemotherapy (CT), and RT (6, 5, 4, and 4 studies, respectively). In meta-analyses, ALND was a risk factor for arm pain (RR [95 % CI] = 1.75 [1.14; 2.71]), lymphedema (RR [95 % CI] = 5.41 [3.48; 8.39]), and overall AS (SMD [95 % CI] = 0.49 [0.14; 0.83]) compared to sentinel lymph node biopsy. RT was not a risk factor, but axillary RT significantly increased overall AS (SMD [95 % CI] = 0.55 [0.40; 0.70]) compared to no axillary RT. Conclusion: ALND and mastectomy were the primary risk factors for patient-reported AS. Axillary RT was a significant risk factor, whereas general RT was not. |
| format | Article |
| id | doaj-art-8f036b9da5b544f19230370b1f38ce2e |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-8f036b9da5b544f19230370b1f38ce2e2024-11-21T06:02:43ZengElsevierBreast1532-30802024-12-0178103812A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impactYuqin Liang0Yuedan Zhou1Ruud Houben2Karolien Verhoeven3Sofia Rivera4Liesbeth J. Boersma5Department of Radiation Oncology (Maastro), GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the Netherlands; Corresponding author. Department of Radiation Oncology (Maastro), GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Centre+, Dr Tanslaan 12, 6229, ET Maastricht, Maastricht, the Netherlands.Department of Radiation Oncology, Centre Hospitalier Universitaire Amiens-Picardie, 1 rond-point du Professeur Christian Cabrol, 80054, Amiens, FranceDepartment of Radiation Oncology (Maastro), GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the NetherlandsDepartment of Radiation Oncology (Maastro), GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the NetherlandsRadiation Oncology Department, Gustave Roussy, F-94805, Villejuif, FranceDepartment of Radiation Oncology (Maastro), GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the NetherlandsObjectives: To systematically review risk factors for patient-reported arm symptoms (AS) in breast cancer (BC), considering radiotherapy (RT) impact, using the EORTC QLQ-BR23 questionnaire (BR23). Methods: PubMed, Embase, Cochrane Library, MEDLINE, and Web of Science were searched using the keywords ''breast neoplasms'', ''radiotherapy'', and ''BR23'' up to March 5th, 2024. Inclusion criteria: both univariate and multivariate analyses. Exclusion criteria: pregnancy, recurrence, distant metastasis BC, reirradiation, or lack of RT. The risk of bias of included papers was assessed using the Critical Appraisal Skills Program (CASP) checklist. Descriptive and meta-analyses were conducted using risk ratio (RR) or standardized mean difference (SMD) with 95 % confidence intervals (CI) as effect measures. A random-effects model was applied if I2 > 50 %. Results: Eighteen out of 734 studies were included, with sample sizes ranging from 172 to 2208. Commonly reported risk factors included axillary lymph node dissection (ALND), mastectomy, chemotherapy (CT), and RT (6, 5, 4, and 4 studies, respectively). In meta-analyses, ALND was a risk factor for arm pain (RR [95 % CI] = 1.75 [1.14; 2.71]), lymphedema (RR [95 % CI] = 5.41 [3.48; 8.39]), and overall AS (SMD [95 % CI] = 0.49 [0.14; 0.83]) compared to sentinel lymph node biopsy. RT was not a risk factor, but axillary RT significantly increased overall AS (SMD [95 % CI] = 0.55 [0.40; 0.70]) compared to no axillary RT. Conclusion: ALND and mastectomy were the primary risk factors for patient-reported AS. Axillary RT was a significant risk factor, whereas general RT was not.http://www.sciencedirect.com/science/article/pii/S0960977624001437Breast cancerPatient-reported outcome measuresArm symptomRisk factorRadiotherapySystematic review |
| spellingShingle | Yuqin Liang Yuedan Zhou Ruud Houben Karolien Verhoeven Sofia Rivera Liesbeth J. Boersma A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact Breast Breast cancer Patient-reported outcome measures Arm symptom Risk factor Radiotherapy Systematic review |
| title | A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact |
| title_full | A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact |
| title_fullStr | A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact |
| title_full_unstemmed | A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact |
| title_short | A systematic review and meta-analysis of risk factors influencing patient-reported arm symptoms post-breast cancer treatment: Accounting for radiotherapy impact |
| title_sort | systematic review and meta analysis of risk factors influencing patient reported arm symptoms post breast cancer treatment accounting for radiotherapy impact |
| topic | Breast cancer Patient-reported outcome measures Arm symptom Risk factor Radiotherapy Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001437 |
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