Lipoprotein(a) throughout life in women
Lipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-atherogenic, pro-thrombotic, and pro-inflammatory features of Lp(a) are associated not only with atherosclerotic vascular disease but also with aortic valve...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | American Journal of Preventive Cardiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666667724002538 |
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| author | Pablo Corral María Gabriela Matta Carlos Aguilar-Salinas Roopa Mehta Gabriela Berg Massimiliano Ruscica Laura Schreier |
| author_facet | Pablo Corral María Gabriela Matta Carlos Aguilar-Salinas Roopa Mehta Gabriela Berg Massimiliano Ruscica Laura Schreier |
| author_sort | Pablo Corral |
| collection | DOAJ |
| description | Lipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-atherogenic, pro-thrombotic, and pro-inflammatory features of Lp(a) are associated not only with atherosclerotic vascular disease but also with aortic valve calcification and all-cause mortality. One of the most interesting aspects of Lp(a) is that its level is determined by genetics in more than 90% of cases, with lifestyle habits having very little influence. Therefore, the recommendation is to test it, at least, once in a lifetime. Contrary to previous beliefs, evidence in recent decades has shown that women have the same or even greater CV risk than men of the same age, attributed to female sex hormones. Different stages of a woman's life can impact on Lp(a) levels, from newborn to menopause, including other critical moments such as menarche and pregnancy. The main objective of this review is to describe and analyze the effect of different specific periods of a woman's life on Lp(a) levels and the potential clinical relevance on their CV risk. |
| format | Article |
| id | doaj-art-8ed091194cb645dc8fcea6fd5ad5cd0f |
| institution | Kabale University |
| issn | 2666-6677 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj-art-8ed091194cb645dc8fcea6fd5ad5cd0f2024-12-11T05:57:44ZengElsevierAmerican Journal of Preventive Cardiology2666-66772024-12-0120100885Lipoprotein(a) throughout life in womenPablo Corral0María Gabriela Matta1Carlos Aguilar-Salinas2Roopa Mehta3Gabriela Berg4Massimiliano Ruscica5Laura Schreier6FASTA University, Pharmacology and Research Department. Instituto Investigaciones Clínicas (IIC), Mar del Plata, Argentina; Corresponding author.FASTA University, Pharmacology and Research Department. Instituto Investigaciones Clínicas (IIC), Mar del Plata, Argentina; Department of Cardiology, Gold Coast University Hospital, Southport, AustraliaUnidad de Investigación de Enfermedades Metabólicas. Departamento de Diabetes y Metabolismo. Dirección de Investigación. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, México City, Mexico; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, LebanonUnidad de Investigación de Enfermedades Metabólicas. Departamento de Diabetes y Metabolismo, México City, MexicoUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC-UBA), Laboratorio de Lípidos y Aterosclerosis, Buenos Aires, ArgentinaDepartment of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Università degli Studi di Milano, Milan, Italy; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, ItalyUniversidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Instituto de Fisiopatología y Bioquímica Clínica (INFIBIOC-UBA), Laboratorio de Lípidos y Aterosclerosis, Buenos Aires, ArgentinaLipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-atherogenic, pro-thrombotic, and pro-inflammatory features of Lp(a) are associated not only with atherosclerotic vascular disease but also with aortic valve calcification and all-cause mortality. One of the most interesting aspects of Lp(a) is that its level is determined by genetics in more than 90% of cases, with lifestyle habits having very little influence. Therefore, the recommendation is to test it, at least, once in a lifetime. Contrary to previous beliefs, evidence in recent decades has shown that women have the same or even greater CV risk than men of the same age, attributed to female sex hormones. Different stages of a woman's life can impact on Lp(a) levels, from newborn to menopause, including other critical moments such as menarche and pregnancy. The main objective of this review is to describe and analyze the effect of different specific periods of a woman's life on Lp(a) levels and the potential clinical relevance on their CV risk.http://www.sciencedirect.com/science/article/pii/S2666667724002538Lipoprotein(a)WomenLipoprotein(a) variability |
| spellingShingle | Pablo Corral María Gabriela Matta Carlos Aguilar-Salinas Roopa Mehta Gabriela Berg Massimiliano Ruscica Laura Schreier Lipoprotein(a) throughout life in women American Journal of Preventive Cardiology Lipoprotein(a) Women Lipoprotein(a) variability |
| title | Lipoprotein(a) throughout life in women |
| title_full | Lipoprotein(a) throughout life in women |
| title_fullStr | Lipoprotein(a) throughout life in women |
| title_full_unstemmed | Lipoprotein(a) throughout life in women |
| title_short | Lipoprotein(a) throughout life in women |
| title_sort | lipoprotein a throughout life in women |
| topic | Lipoprotein(a) Women Lipoprotein(a) variability |
| url | http://www.sciencedirect.com/science/article/pii/S2666667724002538 |
| work_keys_str_mv | AT pablocorral lipoproteinathroughoutlifeinwomen AT mariagabrielamatta lipoproteinathroughoutlifeinwomen AT carlosaguilarsalinas lipoproteinathroughoutlifeinwomen AT roopamehta lipoproteinathroughoutlifeinwomen AT gabrielaberg lipoproteinathroughoutlifeinwomen AT massimilianoruscica lipoproteinathroughoutlifeinwomen AT lauraschreier lipoproteinathroughoutlifeinwomen |