Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report
Sclerosing odontogenic carcinoma (SOC) is a rare intraosseous carcinoma of the jaw which was recently added to the World Health Organization classification of head and neck tumors. We report a case of SOC in the left maxilla of a 64-year-old who complained of several years of midface swelling, facia...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024000256 |
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| author | Leyn B. Shakhtour Jonathan Tucci Barbara Murphy Kim Ely Michael C. Topf |
| author_facet | Leyn B. Shakhtour Jonathan Tucci Barbara Murphy Kim Ely Michael C. Topf |
| author_sort | Leyn B. Shakhtour |
| collection | DOAJ |
| description | Sclerosing odontogenic carcinoma (SOC) is a rare intraosseous carcinoma of the jaw which was recently added to the World Health Organization classification of head and neck tumors. We report a case of SOC in the left maxilla of a 64-year-old who complained of several years of midface swelling, facial pain, and facial weakness. Imaging revealed an infiltrative mass and biopsy demonstrated fibrous dysplasia involved by a low-grade carcinoma, undeterminable origin. A partial maxillectomy was remarkable for scattered small, angulated nests and long, thin cords of cuboidal cells infiltrating a markedly sclerotic stroma. Bony changes consistent with fibrous dysplasia were again seen. Immunohistochemically, the epithelial cells were reactive for AE1/AE3 and p63, while negative for ERG and myogenin consistent with odontogenic carcinoma. The disease was not resectable, and the patient was treated with palliative immunotherapy. The diagnosis of SOC requires careful evaluation of clinical and pathologic features. |
| format | Article |
| id | doaj-art-8ecab72f2909490fa234b854ade4bc73 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-8ecab72f2909490fa234b854ade4bc732025-01-09T06:15:14ZengElsevierOral Oncology Reports2772-90602024-03-019100179Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case reportLeyn B. Shakhtour0Jonathan Tucci1Barbara Murphy2Kim Ely3Michael C. Topf4George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Corresponding author. George Washington University School of Medicine and Health Sciences, 2300 I St NW, Washington, DC, 20052, USA.Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USADivision of Hematology and Oncology, Vanderbilt-Ingram Cancer Center, Nashville, TN, USADepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USASclerosing odontogenic carcinoma (SOC) is a rare intraosseous carcinoma of the jaw which was recently added to the World Health Organization classification of head and neck tumors. We report a case of SOC in the left maxilla of a 64-year-old who complained of several years of midface swelling, facial pain, and facial weakness. Imaging revealed an infiltrative mass and biopsy demonstrated fibrous dysplasia involved by a low-grade carcinoma, undeterminable origin. A partial maxillectomy was remarkable for scattered small, angulated nests and long, thin cords of cuboidal cells infiltrating a markedly sclerotic stroma. Bony changes consistent with fibrous dysplasia were again seen. Immunohistochemically, the epithelial cells were reactive for AE1/AE3 and p63, while negative for ERG and myogenin consistent with odontogenic carcinoma. The disease was not resectable, and the patient was treated with palliative immunotherapy. The diagnosis of SOC requires careful evaluation of clinical and pathologic features.http://www.sciencedirect.com/science/article/pii/S2772906024000256Sclerosing odontogenic carcinomaFibrous dysplasiaSclerosisSkeletal muscle infiltrationHead and neck |
| spellingShingle | Leyn B. Shakhtour Jonathan Tucci Barbara Murphy Kim Ely Michael C. Topf Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report Oral Oncology Reports Sclerosing odontogenic carcinoma Fibrous dysplasia Sclerosis Skeletal muscle infiltration Head and neck |
| title | Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report |
| title_full | Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report |
| title_fullStr | Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report |
| title_full_unstemmed | Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report |
| title_short | Sclerosing odontogenic carcinoma presenting in the maxilla of a 64-year-old female: A case report |
| title_sort | sclerosing odontogenic carcinoma presenting in the maxilla of a 64 year old female a case report |
| topic | Sclerosing odontogenic carcinoma Fibrous dysplasia Sclerosis Skeletal muscle infiltration Head and neck |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024000256 |
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