Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis
BackgroundCoronary atherosclerotic heart disease (coronary heart disease; CHD) is the leading cause of death in women worldwide, and the number of patients and deaths is increasing each year. Approximately 3.8 million women die from CHD every year globally. After menopause, estrogen levels decrease,...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1434149/full |
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| author | Xin Miao Xin Miao Lixing Wu Kuiyue Wang Yuhan Wang Linlin Zhang |
| author_facet | Xin Miao Xin Miao Lixing Wu Kuiyue Wang Yuhan Wang Linlin Zhang |
| author_sort | Xin Miao |
| collection | DOAJ |
| description | BackgroundCoronary atherosclerotic heart disease (coronary heart disease; CHD) is the leading cause of death in women worldwide, and the number of patients and deaths is increasing each year. Approximately 3.8 million women die from CHD every year globally. After menopause, estrogen levels decrease, and the risk of cardiovascular disease increases substantially; however, research on risk factors for CHD in postmenopausal women has been inconclusive.ObjectiveTo systematically evaluate the risk factors for CHD in postmenopausal women.MethodsThe PubMed, Embase, Web of Science, CINAHL, CBM, CNKI, and VIP databases were searched up to February 9, 2024, for studies on risk factors for CHD in postmenopausal women. Two researchers independently screened the literature, extracted data, and evaluated the quality of the included literature. STATA17.0 software was used for meta-analysis.ResultsNine studies involving 29,4103 patients were included. The results of the meta-analysis showed that history of six or more pregnancies (hazard ratio = 1.538, 95% confidence interval: 1.241%–1.906%) was significantly associated with risk of CHD (P < 0.05).ConclusionMultiple pregnancies are associated with CHD incidence and related mortality in postmenopausal women. In the future, more and higher quality studies are needed to further verify this conclusion. |
| format | Article |
| id | doaj-art-8ebc4bc9687b4ca480f48adf49f684ff |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-8ebc4bc9687b4ca480f48adf49f684ff2025-01-13T06:10:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14341491434149Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysisXin Miao0Xin Miao1Lixing Wu2Kuiyue Wang3Yuhan Wang4Linlin Zhang5Department of Nursing, School of Medical and Health Engineering, Changzhou University, Changzhou, Jiangsu, ChinaCardiovascular Medicine Department, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, ChinaCardiovascular Medicine Department, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaThe Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaDepartment of Nursing, School of Medical and Health Engineering, Changzhou University, Changzhou, Jiangsu, ChinaDepartment of Nursing, School of Medical and Health Engineering, Changzhou University, Changzhou, Jiangsu, ChinaBackgroundCoronary atherosclerotic heart disease (coronary heart disease; CHD) is the leading cause of death in women worldwide, and the number of patients and deaths is increasing each year. Approximately 3.8 million women die from CHD every year globally. After menopause, estrogen levels decrease, and the risk of cardiovascular disease increases substantially; however, research on risk factors for CHD in postmenopausal women has been inconclusive.ObjectiveTo systematically evaluate the risk factors for CHD in postmenopausal women.MethodsThe PubMed, Embase, Web of Science, CINAHL, CBM, CNKI, and VIP databases were searched up to February 9, 2024, for studies on risk factors for CHD in postmenopausal women. Two researchers independently screened the literature, extracted data, and evaluated the quality of the included literature. STATA17.0 software was used for meta-analysis.ResultsNine studies involving 29,4103 patients were included. The results of the meta-analysis showed that history of six or more pregnancies (hazard ratio = 1.538, 95% confidence interval: 1.241%–1.906%) was significantly associated with risk of CHD (P < 0.05).ConclusionMultiple pregnancies are associated with CHD incidence and related mortality in postmenopausal women. In the future, more and higher quality studies are needed to further verify this conclusion.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1434149/fullpostmenopausal womencoronary atherosclerotic heart diseaserisk factorsmeta-a nalysisCHD prevention |
| spellingShingle | Xin Miao Xin Miao Lixing Wu Kuiyue Wang Yuhan Wang Linlin Zhang Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis Frontiers in Cardiovascular Medicine postmenopausal women coronary atherosclerotic heart disease risk factors meta-a nalysis CHD prevention |
| title | Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis |
| title_full | Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis |
| title_fullStr | Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis |
| title_full_unstemmed | Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis |
| title_short | Risk factors for coronary atherosclerotic heart disease in postmenopausal women: a meta-analysis |
| title_sort | risk factors for coronary atherosclerotic heart disease in postmenopausal women a meta analysis |
| topic | postmenopausal women coronary atherosclerotic heart disease risk factors meta-a nalysis CHD prevention |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1434149/full |
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