Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients
BackgroundThis study investigated the association between coronary artery calcification (CAC) and triglyceride glucose-body mass index (TyG-BMI) in patients receiving maintenance hemodialysis (MHD).MethodsWe used computed tomography (CT) to assess coronary artery calcification score (CACS) using the...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1478090/full |
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| author | Zexi Jiang Jinhua Zhu Hong Ding Lihong Yan Ruoxin Chen Bin Wang ZuoLin Li Hong Liu |
| author_facet | Zexi Jiang Jinhua Zhu Hong Ding Lihong Yan Ruoxin Chen Bin Wang ZuoLin Li Hong Liu |
| author_sort | Zexi Jiang |
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| description | BackgroundThis study investigated the association between coronary artery calcification (CAC) and triglyceride glucose-body mass index (TyG-BMI) in patients receiving maintenance hemodialysis (MHD).MethodsWe used computed tomography (CT) to assess coronary artery calcification score (CACS) using the Agatston method. The TyG index was multiplied by BMI to derive the TyG-BMI index. Ordinal logistic regression models were used to analyze the relationship between TyG-BMI and CAC. The dose-response relationship was evaluated using restricted cubic spline regression. Weighted Quantile Sum regression was used to explore the weight of the TyG-BMI index components.ResultsBased on the TyG-BMI, 219 patients with MHD were stratified into three groups. The TyG-BMI index was shown to be an independent risk factor for CACS by multivariate ordinal logistic regression analysis (odds ratio, 1.011; [95% confidence interval, 1.002–1.021]; P = 0.021). The relationship between TyG-BMI and lg (CACS + 10) was linear (P-overall = 0.023, P-non-linear = 0.412). Body mass index (BMI) had the highest weight (0.566) when weights were assigned to the three components of TyG-BMI. In the non-diabetes and diabetes subgroups, TyG-BMI and lg (CACS + 10) did not exhibit a significant non-linear relationship.ConclusionTyG-BMI and CAC were independently positively correlated in patients undergoing MHD. These findings suggest that assessing TyG-BMI as a valuable tool for identifying the risk of CAC in patients with MHD. |
| format | Article |
| id | doaj-art-8eb8e3ad468148588db31e4c60d49a32 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-8eb8e3ad468148588db31e4c60d49a322024-12-13T04:17:03ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.14780901478090Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patientsZexi Jiang0Jinhua Zhu1Hong Ding2Lihong Yan3Ruoxin Chen4Bin Wang5ZuoLin Li6Hong Liu7Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong City, Zhenjiang, Jiangsu, ChinaInstitute of Nephrology, People’s Hospital of Yangzhong City, Zhenjiang, Jiangsu, ChinaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaInstitute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, ChinaBackgroundThis study investigated the association between coronary artery calcification (CAC) and triglyceride glucose-body mass index (TyG-BMI) in patients receiving maintenance hemodialysis (MHD).MethodsWe used computed tomography (CT) to assess coronary artery calcification score (CACS) using the Agatston method. The TyG index was multiplied by BMI to derive the TyG-BMI index. Ordinal logistic regression models were used to analyze the relationship between TyG-BMI and CAC. The dose-response relationship was evaluated using restricted cubic spline regression. Weighted Quantile Sum regression was used to explore the weight of the TyG-BMI index components.ResultsBased on the TyG-BMI, 219 patients with MHD were stratified into three groups. The TyG-BMI index was shown to be an independent risk factor for CACS by multivariate ordinal logistic regression analysis (odds ratio, 1.011; [95% confidence interval, 1.002–1.021]; P = 0.021). The relationship between TyG-BMI and lg (CACS + 10) was linear (P-overall = 0.023, P-non-linear = 0.412). Body mass index (BMI) had the highest weight (0.566) when weights were assigned to the three components of TyG-BMI. In the non-diabetes and diabetes subgroups, TyG-BMI and lg (CACS + 10) did not exhibit a significant non-linear relationship.ConclusionTyG-BMI and CAC were independently positively correlated in patients undergoing MHD. These findings suggest that assessing TyG-BMI as a valuable tool for identifying the risk of CAC in patients with MHD.https://www.frontiersin.org/articles/10.3389/fmed.2024.1478090/fulltriglyceride glucose-body mass indexcoronary artery calcificationcardiovascular diseasemaintenance hemodialysisinsulin resistance |
| spellingShingle | Zexi Jiang Jinhua Zhu Hong Ding Lihong Yan Ruoxin Chen Bin Wang ZuoLin Li Hong Liu Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients Frontiers in Medicine triglyceride glucose-body mass index coronary artery calcification cardiovascular disease maintenance hemodialysis insulin resistance |
| title | Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients |
| title_full | Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients |
| title_fullStr | Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients |
| title_full_unstemmed | Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients |
| title_short | Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients |
| title_sort | relationship between triglyceride glucose body mass index and coronary artery calcium score in maintenance hemodialysis patients |
| topic | triglyceride glucose-body mass index coronary artery calcification cardiovascular disease maintenance hemodialysis insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1478090/full |
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