Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis
The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different strains. Thus, 6 B. coagulans strains were tested in the present study using an irritable bowel syndrome (IBS) animal model to determine whether the IBS-alleviating effects of B. co...
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Tsinghua University Press
2024-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250153 |
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| author | Jiang Cao Leilei Yu Jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao Zhai |
| author_facet | Jiang Cao Leilei Yu Jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao Zhai |
| author_sort | Jiang Cao |
| collection | DOAJ |
| description | The high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different strains. Thus, 6 B. coagulans strains were tested in the present study using an irritable bowel syndrome (IBS) animal model to determine whether the IBS-alleviating effects of B. coagulans strains are strain-specific. The results of this study showed that the ingestion of B. coagulans GBI-30, 6086, and B. coagulans CCFM1041 significantly alleviated IBS symptoms in mice. In contrast, other B. coagulans strains showed no or limited alleviating effects on IBS symptoms. According to our experimental results, the two main common features of these strains were as follows: 1) The resistance of vegetative cells to bile salts, and 2) ability to synthesize specific lipids and secondary metabolites. Screening strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional B. coagulans strains. Our results also suggest that administration of B. coagulans could significantly regulate microbiota dysbiosis in animal models. Moreover, the close relationships between the gut microbiota, gut microbiota metabolites, and IBS were further confirmed in this study. |
| format | Article |
| id | doaj-art-8e8bf708a509486e870e8abceefad5f4 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-8e8bf708a509486e870e8abceefad5f42025-01-10T06:56:47ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-07-011341845185510.26599/FSHW.2022.9250153Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysisJiang Cao0Leilei Yu1Jianxin Zhao2Hao Zhang3Wei Chen4Yuzheng Xue5Qixiao Zhai6State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaDepartment of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaThe high intraspecies heterogeneity of Baciillus coagulans leads to significant phenotypic differences among different strains. Thus, 6 B. coagulans strains were tested in the present study using an irritable bowel syndrome (IBS) animal model to determine whether the IBS-alleviating effects of B. coagulans strains are strain-specific. The results of this study showed that the ingestion of B. coagulans GBI-30, 6086, and B. coagulans CCFM1041 significantly alleviated IBS symptoms in mice. In contrast, other B. coagulans strains showed no or limited alleviating effects on IBS symptoms. According to our experimental results, the two main common features of these strains were as follows: 1) The resistance of vegetative cells to bile salts, and 2) ability to synthesize specific lipids and secondary metabolites. Screening strains based on these two indicators may greatly reduce costs and provide a basis for mining new functional B. coagulans strains. Our results also suggest that administration of B. coagulans could significantly regulate microbiota dysbiosis in animal models. Moreover, the close relationships between the gut microbiota, gut microbiota metabolites, and IBS were further confirmed in this study.https://www.sciopen.com/article/10.26599/FSHW.2022.9250153baciillus coagulansirritable bowel syndromeresistance to bile saltscomparative genomic analysisgut microbiota |
| spellingShingle | Jiang Cao Leilei Yu Jianxin Zhao Hao Zhang Wei Chen Yuzheng Xue Qixiao Zhai Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis Food Science and Human Wellness baciillus coagulans irritable bowel syndrome resistance to bile salts comparative genomic analysis gut microbiota |
| title | Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis |
| title_full | Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis |
| title_fullStr | Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis |
| title_full_unstemmed | Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis |
| title_short | Alleviative effects of Bacillus coagulans strains on irritable bowel syndrome-unraveling strain specificity through physiological and genomic analysis |
| title_sort | alleviative effects of bacillus coagulans strains on irritable bowel syndrome unraveling strain specificity through physiological and genomic analysis |
| topic | baciillus coagulans irritable bowel syndrome resistance to bile salts comparative genomic analysis gut microbiota |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250153 |
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