Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study
Abstract Background This study explored the influence of type 2 diabetes and impaired glucose tolerance (IGT) on the risk of the multimorbidity cluster of cardiovascular disease (CVD) and cancer. Methods A total of 1629 participants in the Da Qing Diabetes Prevention Outcome Study were recruited in...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
|
| Series: | BMC Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12916-024-03749-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846165132226330624 |
|---|---|
| author | Fei Chen Jinping Wang Siyao He Yifan He Yali An Qiuhong Gong Xiaoping Chen Ying Shuai Xuan Wang Yanyan Chen Bo Zhang Guangwei Li |
| author_facet | Fei Chen Jinping Wang Siyao He Yifan He Yali An Qiuhong Gong Xiaoping Chen Ying Shuai Xuan Wang Yanyan Chen Bo Zhang Guangwei Li |
| author_sort | Fei Chen |
| collection | DOAJ |
| description | Abstract Background This study explored the influence of type 2 diabetes and impaired glucose tolerance (IGT) on the risk of the multimorbidity cluster of cardiovascular disease (CVD) and cancer. Methods A total of 1629 participants in the Da Qing Diabetes Prevention Outcome Study were recruited in the present analysis, including normal glucose tolerance (NGT, N = 492), IGT (N = 540), and newly diagnosed type 2 diabetes (N = 597) groups. Cox proportional hazards analyses were performed to assess the relationship between NGT, IGT, and newly diagnosed type 2 diabetes and the risk of the multimorbidity cluster of CVD and cancer. Results The incidence rates for multimorbidity cluster CVD and cancer were 1.25, 3.17, and 3.23 per 1000 person-years in people with NGT, IGT, and the newly diagnosed type 2 diabetes groups, respectively, over 34-year follow-up. Cox analysis revealed that diabetes status (as time-dependent variable) was significantly associated with the subsequent increased risk of multimorbidity cluster of CVD and cancer compared with non-diabetes (hazard ratios [HR] = 2.55, 95% confidence interval [CI] 1.51–4.31) after adjustment of potential confounders. Similar analysis showed that this risk was significantly higher in the IGT and newly diagnosed type 2 diabetes groups compared with NGT, with HR of 3.28 (95% CI 1.83–5.87) and HR of 3.90 (95% CI 2.14–7.09), respectively. Whereas compared diabetes with IGT group, this risk was not significantly different. Conclusions Similar to newly diagnosed type 2 diabetes, IGT is significantly associated with an increased risk of the multimorbidity cluster of CVD and cancer compared with NGT. This finding highlights the urgent need for an active detection of IGT and effective prevention and management of diabetes. |
| format | Article |
| id | doaj-art-8e7eda037e424013b9f69d515f333663 |
| institution | Kabale University |
| issn | 1741-7015 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-8e7eda037e424013b9f69d515f3336632024-11-17T12:32:14ZengBMCBMC Medicine1741-70152024-11-0122111010.1186/s12916-024-03749-6Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome StudyFei Chen0Jinping Wang1Siyao He2Yifan He3Yali An4Qiuhong Gong5Xiaoping Chen6Ying Shuai7Xuan Wang8Yanyan Chen9Bo Zhang10Guangwei Li11Department of Endocrinology, China-Japan Friendship HospitalDepartment of Cardiology, Da Qing First HospitalCenter of Endocrinology, National Center of Cardiology & Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Endocrinology, China-Japan Friendship HospitalCenter of Endocrinology, National Center of Cardiology & Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter of Endocrinology, National Center of Cardiology & Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Endocrinology, China-Japan Friendship HospitalDepartment of Endocrinology, China-Japan Friendship HospitalCenter of Endocrinology, National Center of Cardiology & Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter of Endocrinology, National Center of Cardiology & Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Endocrinology, China-Japan Friendship HospitalDepartment of Endocrinology, China-Japan Friendship HospitalAbstract Background This study explored the influence of type 2 diabetes and impaired glucose tolerance (IGT) on the risk of the multimorbidity cluster of cardiovascular disease (CVD) and cancer. Methods A total of 1629 participants in the Da Qing Diabetes Prevention Outcome Study were recruited in the present analysis, including normal glucose tolerance (NGT, N = 492), IGT (N = 540), and newly diagnosed type 2 diabetes (N = 597) groups. Cox proportional hazards analyses were performed to assess the relationship between NGT, IGT, and newly diagnosed type 2 diabetes and the risk of the multimorbidity cluster of CVD and cancer. Results The incidence rates for multimorbidity cluster CVD and cancer were 1.25, 3.17, and 3.23 per 1000 person-years in people with NGT, IGT, and the newly diagnosed type 2 diabetes groups, respectively, over 34-year follow-up. Cox analysis revealed that diabetes status (as time-dependent variable) was significantly associated with the subsequent increased risk of multimorbidity cluster of CVD and cancer compared with non-diabetes (hazard ratios [HR] = 2.55, 95% confidence interval [CI] 1.51–4.31) after adjustment of potential confounders. Similar analysis showed that this risk was significantly higher in the IGT and newly diagnosed type 2 diabetes groups compared with NGT, with HR of 3.28 (95% CI 1.83–5.87) and HR of 3.90 (95% CI 2.14–7.09), respectively. Whereas compared diabetes with IGT group, this risk was not significantly different. Conclusions Similar to newly diagnosed type 2 diabetes, IGT is significantly associated with an increased risk of the multimorbidity cluster of CVD and cancer compared with NGT. This finding highlights the urgent need for an active detection of IGT and effective prevention and management of diabetes.https://doi.org/10.1186/s12916-024-03749-6Impaired glucose toleranceType 2 diabetesMultimorbidityCardiovascular diseaseCancer |
| spellingShingle | Fei Chen Jinping Wang Siyao He Yifan He Yali An Qiuhong Gong Xiaoping Chen Ying Shuai Xuan Wang Yanyan Chen Bo Zhang Guangwei Li Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study BMC Medicine Impaired glucose tolerance Type 2 diabetes Multimorbidity Cardiovascular disease Cancer |
| title | Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study |
| title_full | Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study |
| title_fullStr | Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study |
| title_full_unstemmed | Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study |
| title_short | Influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer: a post hoc analysis of the Da Qing Diabetes Prevention Outcome Study |
| title_sort | influence of impaired glucose tolerance and type 2 diabetes on the multimorbidity cluster of cardiovascular disease and cancer a post hoc analysis of the da qing diabetes prevention outcome study |
| topic | Impaired glucose tolerance Type 2 diabetes Multimorbidity Cardiovascular disease Cancer |
| url | https://doi.org/10.1186/s12916-024-03749-6 |
| work_keys_str_mv | AT feichen influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT jinpingwang influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT siyaohe influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT yifanhe influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT yalian influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT qiuhonggong influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT xiaopingchen influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT yingshuai influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT xuanwang influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT yanyanchen influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT bozhang influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy AT guangweili influenceofimpairedglucosetoleranceandtype2diabetesonthemultimorbidityclusterofcardiovasculardiseaseandcanceraposthocanalysisofthedaqingdiabetespreventionoutcomestudy |