Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report
The treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to the drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) is an orally small molecule agents target SARS-CoV-2 RdRp and inhibits viral replication. I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501813/full |
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| author | Jiaying Zhang Yuan Gao Xiaoyun Miao Wei Wang Zhongkai Zhou Yunyi Gao Liwei Liu Menghua Wu Ke Ma Ling Zhou Yan Yang Sha Meng Yingmei Feng Zhuorui Zhao Wei Liu Danlei Mou Zixin Kang Lianchun Liang Zhongjie Hu |
| author_facet | Jiaying Zhang Yuan Gao Xiaoyun Miao Wei Wang Zhongkai Zhou Yunyi Gao Liwei Liu Menghua Wu Ke Ma Ling Zhou Yan Yang Sha Meng Yingmei Feng Zhuorui Zhao Wei Liu Danlei Mou Zixin Kang Lianchun Liang Zhongjie Hu |
| author_sort | Jiaying Zhang |
| collection | DOAJ |
| description | The treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to the drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) is an orally small molecule agents target SARS-CoV-2 RdRp and inhibits viral replication. It may have a low likelihood of drug-drug interactions and has a potential to provide new treatment option. We described three cases of renal transplant patients with concomitant impaired renal function who developed COVID-19 pneumonia and were treated with VV116. Despite varying degrees of drug accumulation, these patients achieved rapid viral clearance and showed prompt improvement in pneumonia symptoms. Notably, tacrolimus blood concentrations remained within the therapeutic range throughout treatment, and no clinically significant adverse events were observed despite the drug accumulation. |
| format | Article |
| id | doaj-art-8e70a935661b478d97ed9f62695ef4a3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8e70a935661b478d97ed9f62695ef4a32025-01-17T06:51:08ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15018131501813Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series reportJiaying Zhang0Yuan Gao1Xiaoyun Miao2Wei Wang3Zhongkai Zhou4Yunyi Gao5Liwei Liu6Menghua Wu7Ke Ma8Ling Zhou9Yan Yang10Sha Meng11Yingmei Feng12Zhuorui Zhao13Wei Liu14Danlei Mou15Zixin Kang16Lianchun Liang17Zhongjie Hu18Department of Infectious Disease, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaFourth Department of Liver Disease, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Critical Care Medicine, Cangzhou Central Hospital, Cangzhou, Hebei, ChinaDepartment of Radiology, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaSafe Transfusion Lab, Beijing Red Cross Blood Center, Beijing, ChinaFourth Department of Liver Disease, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Urology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaDepartment of Bioanalysis, United-Power Pharma Tech Co., Ltd, Shanghai, ChinaDepartment of Bioanalysis, United-Power Pharma Tech Co., Ltd, Shanghai, ChinaDepartment of Bioanalysis, United-Power Pharma Tech Co., Ltd, Shanghai, ChinaDepartment of Science and Technology, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Science and Technology, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Medicine, Xenorm MedInfo Center, Beijing, China0Department of Pharmacy, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Disease, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Disease, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaDepartment of Infectious Disease, Beijing You’An Hospital, Capital Medical University, Beijing, China1Liver Disease Center, Beijing You’An Hospital, Capital Medical University, Beijing, ChinaThe treatment of COVID-19 in the post-transplant individuals is challenging, primarily due to the drug-drug interaction between nirmatrelvir/ritonavir and tacrolimus. Deuremidevir hydrobromide tablets (VV116) is an orally small molecule agents target SARS-CoV-2 RdRp and inhibits viral replication. It may have a low likelihood of drug-drug interactions and has a potential to provide new treatment option. We described three cases of renal transplant patients with concomitant impaired renal function who developed COVID-19 pneumonia and were treated with VV116. Despite varying degrees of drug accumulation, these patients achieved rapid viral clearance and showed prompt improvement in pneumonia symptoms. Notably, tacrolimus blood concentrations remained within the therapeutic range throughout treatment, and no clinically significant adverse events were observed despite the drug accumulation.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501813/fullCOVID-19organ transplantkidney dysfunctiondrug accumulationVV116 |
| spellingShingle | Jiaying Zhang Yuan Gao Xiaoyun Miao Wei Wang Zhongkai Zhou Yunyi Gao Liwei Liu Menghua Wu Ke Ma Ling Zhou Yan Yang Sha Meng Yingmei Feng Zhuorui Zhao Wei Liu Danlei Mou Zixin Kang Lianchun Liang Zhongjie Hu Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report Frontiers in Immunology COVID-19 organ transplant kidney dysfunction drug accumulation VV116 |
| title | Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report |
| title_full | Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report |
| title_fullStr | Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report |
| title_full_unstemmed | Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report |
| title_short | Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report |
| title_sort | severe metabolic accumulation of vv116 in kidney transplant patients with impaired renal function a case series report |
| topic | COVID-19 organ transplant kidney dysfunction drug accumulation VV116 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1501813/full |
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