Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma

Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma

Abstract Undifferentiated pleomorphic sarcoma (UPS) and related tumors are the most common type of soft tissue sarcoma. However, this spectrum of tumors has different etiologies with varying rates of metastasis and survival. Two dermal-based neoplasms in this class of pleomorphic sarcomas, atypical...

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Bibliographic Details
Main Authors: Jason C. Klein, Lei Wang, Douglas Strand, Chewlan Lastufka, Gregory A. Hosler, Gary C. Hon
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Cancer
Subjects:
Sarcoma
Prognosis
Biomarker
Single-cell transcriptomics
Spatial transcriptomics
Collagen
Online Access:https://doi.org/10.1186/s12943-024-02168-8
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