In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice
IntroductionThe control of parasites infections in livestock is an ongoing concern, with parasites developing resistance to commonly used antiparasitic drugs. The current study investigated in vitro the destructive effect of the fungus Pochonia chlamydosporia on the eggs and oocysts of several equin...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1505824/full |
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| author | Yuan Ma Yuan Ma Yuan Ma Jinbao Lv Lili Jiang Zhaobin Fan Luyao Hao Luyao Hao Luyao Hao Zhengyi Li Zhengyi Li Zhengyi Li Chengyu Ma Chengyu Ma Chengyu Ma Rui Wang Rui Wang Rui Wang Hongliang Luo |
| author_facet | Yuan Ma Yuan Ma Yuan Ma Jinbao Lv Lili Jiang Zhaobin Fan Luyao Hao Luyao Hao Luyao Hao Zhengyi Li Zhengyi Li Zhengyi Li Chengyu Ma Chengyu Ma Chengyu Ma Rui Wang Rui Wang Rui Wang Hongliang Luo |
| author_sort | Yuan Ma |
| collection | DOAJ |
| description | IntroductionThe control of parasites infections in livestock is an ongoing concern, with parasites developing resistance to commonly used antiparasitic drugs. The current study investigated in vitro the destructive effect of the fungus Pochonia chlamydosporia on the eggs and oocysts of several equine parasites, as well as assessing the safety of the fungus in mice.MethodsS. equinus, P. equorum, Anoplocephala spp eggs and Eimeria spp. oocysts were treated with P. chlamydosporia. The prepared preparation was also administered to mice, and the physiological indexes and lesions of major tissues and organs, as well as pathological sections of tissue, were then observed.ResultsP. chlamydosporia exhibited varying degrees of efficacy in the control of S. equinus, P. equorum, Anoplocephala spp eggs and Eimeria spp. oocysts. The acute toxicity test demonstrated that there was no death or toxicity symptom observed in the mice, with no significant difference in clinical observations, such as respiration, mental state, appetite, or feces, between the control and treated mice after the feeding of the biological preparation of P. chlamydosporia.DiscussionThese findings suggested that administration of P. chlamydosporia would be safe to use in livestock and provided a rationale for its potential clinical application, pending further analyses. |
| format | Article |
| id | doaj-art-8e0c4e704caf4dba8beab4ff175665e9 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-8e0c4e704caf4dba8beab4ff175665e92025-01-09T18:25:32ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15058241505824In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on miceYuan Ma0Yuan Ma1Yuan Ma2Jinbao Lv3Lili Jiang4Zhaobin Fan5Luyao Hao6Luyao Hao7Luyao Hao8Zhengyi Li9Zhengyi Li10Zhengyi Li11Chengyu Ma12Chengyu Ma13Chengyu Ma14Rui Wang15Rui Wang16Rui Wang17Hongliang Luo18College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, ChinaKey Laboratory of Clinical Diagnosis and Treatment of Animal Diseases, Ministry of Agriculture, National Animal Medicine Experimental Teaching Center, Hohhot, ChinaNational Center of Technology Innovation for Dairy, Hohhot, ChinaZhongnong Dong Jun Animal Diagnosis Technology (Beijing) Co., Ltd., Beijing, ChinaCollege of Pharmacy Heze University, Heze, ChinaCollege of Pharmacy Heze University, Heze, ChinaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, ChinaKey Laboratory of Clinical Diagnosis and Treatment of Animal Diseases, Ministry of Agriculture, National Animal Medicine Experimental Teaching Center, Hohhot, ChinaNational Center of Technology Innovation for Dairy, Hohhot, ChinaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, ChinaKey Laboratory of Clinical Diagnosis and Treatment of Animal Diseases, Ministry of Agriculture, National Animal Medicine Experimental Teaching Center, Hohhot, ChinaNational Center of Technology Innovation for Dairy, Hohhot, ChinaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, ChinaKey Laboratory of Clinical Diagnosis and Treatment of Animal Diseases, Ministry of Agriculture, National Animal Medicine Experimental Teaching Center, Hohhot, ChinaNational Center of Technology Innovation for Dairy, Hohhot, ChinaCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, ChinaKey Laboratory of Clinical Diagnosis and Treatment of Animal Diseases, Ministry of Agriculture, National Animal Medicine Experimental Teaching Center, Hohhot, ChinaNational Center of Technology Innovation for Dairy, Hohhot, ChinaRui Pu Agricultural Technology Co., Ltd., Hohhot, ChinaIntroductionThe control of parasites infections in livestock is an ongoing concern, with parasites developing resistance to commonly used antiparasitic drugs. The current study investigated in vitro the destructive effect of the fungus Pochonia chlamydosporia on the eggs and oocysts of several equine parasites, as well as assessing the safety of the fungus in mice.MethodsS. equinus, P. equorum, Anoplocephala spp eggs and Eimeria spp. oocysts were treated with P. chlamydosporia. The prepared preparation was also administered to mice, and the physiological indexes and lesions of major tissues and organs, as well as pathological sections of tissue, were then observed.ResultsP. chlamydosporia exhibited varying degrees of efficacy in the control of S. equinus, P. equorum, Anoplocephala spp eggs and Eimeria spp. oocysts. The acute toxicity test demonstrated that there was no death or toxicity symptom observed in the mice, with no significant difference in clinical observations, such as respiration, mental state, appetite, or feces, between the control and treated mice after the feeding of the biological preparation of P. chlamydosporia.DiscussionThese findings suggested that administration of P. chlamydosporia would be safe to use in livestock and provided a rationale for its potential clinical application, pending further analyses.https://www.frontiersin.org/articles/10.3389/fvets.2024.1505824/fullbiocontrolP. chlamydosporiaeggstoxicitymiceparasites |
| spellingShingle | Yuan Ma Yuan Ma Yuan Ma Jinbao Lv Lili Jiang Zhaobin Fan Luyao Hao Luyao Hao Luyao Hao Zhengyi Li Zhengyi Li Zhengyi Li Chengyu Ma Chengyu Ma Chengyu Ma Rui Wang Rui Wang Rui Wang Hongliang Luo In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice Frontiers in Veterinary Science biocontrol P. chlamydosporia eggs toxicity mice parasites |
| title | In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice |
| title_full | In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice |
| title_fullStr | In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice |
| title_full_unstemmed | In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice |
| title_short | In vitro ovicidal studies on egg-parasitic fungus Pochonia chlamydosporia and safety tests on mice |
| title_sort | in vitro ovicidal studies on egg parasitic fungus pochonia chlamydosporia and safety tests on mice |
| topic | biocontrol P. chlamydosporia eggs toxicity mice parasites |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1505824/full |
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