Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy
The tumor microenvironment (TME) fosters cancer progression by supporting the differentiation and proliferation of myeloid‐derived suppressor cells (MDSCs), which play a critical role in suppressing immune responses and facilitating tumor growth. Recent findings by Dahal et al. reveal that platelet‐...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Molecular Oncology |
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| Online Access: | https://doi.org/10.1002/1878-0261.13758 |
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| _version_ | 1841556045142425600 |
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| author | Qi Yan Hemn Mohammadpour |
| author_facet | Qi Yan Hemn Mohammadpour |
| author_sort | Qi Yan |
| collection | DOAJ |
| description | The tumor microenvironment (TME) fosters cancer progression by supporting the differentiation and proliferation of myeloid‐derived suppressor cells (MDSCs), which play a critical role in suppressing immune responses and facilitating tumor growth. Recent findings by Dahal et al. reveal that platelet‐activating factor (PAF), a lipid mediator elevated in the TME, contributes to the differentiation of neutrophils into immunosuppressive neutrophils. They showed that inhibiting PAF signaling reduces MDSC‐mediated immunosuppression, thereby enhancing cytotoxic T‐cell activity. This approach may improve cancer immunotherapy outcomes, particularly when combined with checkpoint blockade therapies, suggesting a promising avenue for therapeutic development. |
| format | Article |
| id | doaj-art-8e09ad54428d4e01b35ea2d754f1090c |
| institution | Kabale University |
| issn | 1574-7891 1878-0261 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Oncology |
| spelling | doaj-art-8e09ad54428d4e01b35ea2d754f1090c2025-01-07T14:42:32ZengWileyMolecular Oncology1574-78911878-02612025-01-01191111410.1002/1878-0261.13758Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapyQi Yan0Hemn Mohammadpour1Department of Cell Stress Biology Roswell Park Comprehensive Cancer Center Buffalo NY USADepartment of Cell Stress Biology Roswell Park Comprehensive Cancer Center Buffalo NY USAThe tumor microenvironment (TME) fosters cancer progression by supporting the differentiation and proliferation of myeloid‐derived suppressor cells (MDSCs), which play a critical role in suppressing immune responses and facilitating tumor growth. Recent findings by Dahal et al. reveal that platelet‐activating factor (PAF), a lipid mediator elevated in the TME, contributes to the differentiation of neutrophils into immunosuppressive neutrophils. They showed that inhibiting PAF signaling reduces MDSC‐mediated immunosuppression, thereby enhancing cytotoxic T‐cell activity. This approach may improve cancer immunotherapy outcomes, particularly when combined with checkpoint blockade therapies, suggesting a promising avenue for therapeutic development.https://doi.org/10.1002/1878-0261.13758immune therapyMDSCneutrophilPAFtumor microenvironment |
| spellingShingle | Qi Yan Hemn Mohammadpour Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy Molecular Oncology immune therapy MDSC neutrophil PAF tumor microenvironment |
| title | Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy |
| title_full | Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy |
| title_fullStr | Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy |
| title_full_unstemmed | Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy |
| title_short | Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy |
| title_sort | platelet activating factor a potential therapeutic target to improve cancer immunotherapy |
| topic | immune therapy MDSC neutrophil PAF tumor microenvironment |
| url | https://doi.org/10.1002/1878-0261.13758 |
| work_keys_str_mv | AT qiyan plateletactivatingfactorapotentialtherapeutictargettoimprovecancerimmunotherapy AT hemnmohammadpour plateletactivatingfactorapotentialtherapeutictargettoimprovecancerimmunotherapy |