Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system
CRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications. CRISPR-Cas systems can be categorized into six different types ba...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024155697 |
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| author | Hui Cheng Haoyue Deng Dongdao Ma Mengyuan Gao Zhihan Zhou Heng Li Shejuan Liu Tieshan Teng |
| author_facet | Hui Cheng Haoyue Deng Dongdao Ma Mengyuan Gao Zhihan Zhou Heng Li Shejuan Liu Tieshan Teng |
| author_sort | Hui Cheng |
| collection | DOAJ |
| description | CRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications. CRISPR-Cas systems can be categorized into six different types based on their composition and mechanism, and there are also natural regulatory biomolecules in bacteria and bacteriophages that can either enhance or inhibit the immune function of CRISPR-Cas. The CRISPR-Cas systems are currently being trialed as a new tool for gene therapy to treat various human diseases, including cancers and genetic diseases, offering significant therapeutic potential. This paper comprehensively summarizes various aspects of the CRISPR-Cas system, encompassing its diversity, regulatory mechanisms, its clinical applications and the obstacles encountered. |
| format | Article |
| id | doaj-art-8dfe70d9f09540d9b0d07040afccc4d4 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-8dfe70d9f09540d9b0d07040afccc4d42024-11-12T05:20:54ZengElsevierHeliyon2405-84402024-10-011020e39538Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas systemHui Cheng0Haoyue Deng1Dongdao Ma2Mengyuan Gao3Zhihan Zhou4Heng Li5Shejuan Liu6Tieshan Teng7School of Basic Medical Sciences, Henan University, Kaifeng, 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, 475004, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, 475004, ChinaSchool of Medical Laboratory, Weifang Medical University, Weifang, 261053, Shandong, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Corresponding author.School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Corresponding author.CRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications. CRISPR-Cas systems can be categorized into six different types based on their composition and mechanism, and there are also natural regulatory biomolecules in bacteria and bacteriophages that can either enhance or inhibit the immune function of CRISPR-Cas. The CRISPR-Cas systems are currently being trialed as a new tool for gene therapy to treat various human diseases, including cancers and genetic diseases, offering significant therapeutic potential. This paper comprehensively summarizes various aspects of the CRISPR-Cas system, encompassing its diversity, regulatory mechanisms, its clinical applications and the obstacles encountered.http://www.sciencedirect.com/science/article/pii/S2405844024155697CRISPR-CasGenome editingRegulatory mechanismClinical applications |
| spellingShingle | Hui Cheng Haoyue Deng Dongdao Ma Mengyuan Gao Zhihan Zhou Heng Li Shejuan Liu Tieshan Teng Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system Heliyon CRISPR-Cas Genome editing Regulatory mechanism Clinical applications |
| title | Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system |
| title_full | Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system |
| title_fullStr | Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system |
| title_full_unstemmed | Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system |
| title_short | Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system |
| title_sort | insight into the natural regulatory mechanisms and clinical applications of the crispr cas system |
| topic | CRISPR-Cas Genome editing Regulatory mechanism Clinical applications |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024155697 |
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