Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment

Deep-amplicon sequencing of the complete beta-tubulin gene in Trichuris trichiura before and after albendazole treatment

Concerns about the emergence of benzimidazole resistance in soil-transmitted helminths (STH) infections, particularly against Trichuris trichiura, have arisen. Previous studies of veterinary nematodes have linked benzimidazole resistance to single-nucleotide polymorphisms (SNPs) at three specific co...

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Main Authors: Javier Gandasegui, Berta Grau-Pujol, Valdemiro Novela, Osvaldo Muchisse, Maria Cambra-Pellejà, Anélsio Cossa, José Carlos Jamine, Charfudin Sacoor, Eric A.T. Brienen, Francesc Catala-Moll, Lisette van Lieshout, María Martínez-Valladares, Roger Paredes, José Muñoz, Stephen R. Doyle
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Trichuris trichiura
Deep-amplicon sequencing
Beta-tubulin
Benzimidazole resistance
Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320724000514
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