Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers
<b>Aim: </b>It is aimed to determine the preventive effect of black seed (Nigella sativa L; NS) and its pharmaceutically active substance volatile fatty acid thymoquinone on relative liver weight increase in broiler in aflatoxicosis..<p> <b>Materials and Methods:</b> On...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2020-06-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1286 |
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| _version_ | 1841561424606789632 |
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| author | Mehmet Burak Ateş Mustafa Ortatatlı |
| author_facet | Mehmet Burak Ateş Mustafa Ortatatlı |
| author_sort | Mehmet Burak Ateş |
| collection | DOAJ |
| description | <b>Aim: </b>It is aimed to determine the preventive effect of black seed (Nigella
sativa L; NS) and its pharmaceutically active substance volatile
fatty acid thymoquinone on relative liver weight increase in broiler
in aflatoxicosis..<p>
<b>Materials and Methods:</b> One hundred twenty 1-d-old broiler chicks
were used and divided into 6 equal groups and fed for 28 days. Animals
were received feed with 2 mg/kg total aflatoxin (AF; AFB1,
AFB2, AFG1 and AFG2), 5% black seed (NS) and 300 mg/kg thymoquinone
(TQ), according to the groups; Control, AF, NS, TQ, AF+NS
and AF+TQ. At the end of the experiment, euthanasia was performed
by decapitation after determination of the live weight of ten broiler
chickens in all groups, and systemic necropsies were performed.
The liver, the main target organ for AF, was removed and weighed
to determine relative organ weight. The relative liver weights were
calculated as % (liver weight x 100 / live body weight).<p>
<b>Results:</b> Aflatotoxin application significantly increased the relative
weight of the liver (P<0,01). While the difference was not significant
in the TQ group compared to the control group, a significant increase
in liver weight was found in the NS group. Addition of TQ to feeds
with AF significantly reduced the relative liver weight values to normal.
NS effect was found more partial compared to TQ.<p>
<b>Conclusion:</b> In conclusion, it was thought that TQ and NS prevented
the relative liver weight increase, an important biomarker for aflatoxicosis,
by probably ameliorating lipid metabolism and transport
which is impaired by the toxic effect of AF. |
| format | Article |
| id | doaj-art-8dc4e8b196144ded92dcb678e80ea22a |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-8dc4e8b196144ded92dcb678e80ea22a2025-01-03T01:36:25ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532020-06-013621071141286Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilersMehmet Burak AteşMustafa Ortatatlı<b>Aim: </b>It is aimed to determine the preventive effect of black seed (Nigella sativa L; NS) and its pharmaceutically active substance volatile fatty acid thymoquinone on relative liver weight increase in broiler in aflatoxicosis..<p> <b>Materials and Methods:</b> One hundred twenty 1-d-old broiler chicks were used and divided into 6 equal groups and fed for 28 days. Animals were received feed with 2 mg/kg total aflatoxin (AF; AFB1, AFB2, AFG1 and AFG2), 5% black seed (NS) and 300 mg/kg thymoquinone (TQ), according to the groups; Control, AF, NS, TQ, AF+NS and AF+TQ. At the end of the experiment, euthanasia was performed by decapitation after determination of the live weight of ten broiler chickens in all groups, and systemic necropsies were performed. The liver, the main target organ for AF, was removed and weighed to determine relative organ weight. The relative liver weights were calculated as % (liver weight x 100 / live body weight).<p> <b>Results:</b> Aflatotoxin application significantly increased the relative weight of the liver (P<0,01). While the difference was not significant in the TQ group compared to the control group, a significant increase in liver weight was found in the NS group. Addition of TQ to feeds with AF significantly reduced the relative liver weight values to normal. NS effect was found more partial compared to TQ.<p> <b>Conclusion:</b> In conclusion, it was thought that TQ and NS prevented the relative liver weight increase, an important biomarker for aflatoxicosis, by probably ameliorating lipid metabolism and transport which is impaired by the toxic effect of AF.http://eurasianjvetsci.org/pdf.php3?id=1286aflatoxicosisthymoquinonenigella sativaliverrelative weight |
| spellingShingle | Mehmet Burak Ateş Mustafa Ortatatlı Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers Eurasian Journal of Veterinary Sciences aflatoxicosis thymoquinone nigella sativa liver relative weight |
| title | Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers |
| title_full | Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers |
| title_fullStr | Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers |
| title_full_unstemmed | Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers |
| title_short | Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers |
| title_sort | protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers |
| topic | aflatoxicosis thymoquinone nigella sativa liver relative weight |
| url | http://eurasianjvetsci.org/pdf.php3?id=1286 |
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