Protective effect of nigella sativa and thymoquinone on relative liver weight increase caused by aflatoxin in broilers
<b>Aim: </b>It is aimed to determine the preventive effect of black seed (Nigella sativa L; NS) and its pharmaceutically active substance volatile fatty acid thymoquinone on relative liver weight increase in broiler in aflatoxicosis..<p> <b>Materials and Methods:</b> On...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
2020-06-01
|
| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1286 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <b>Aim: </b>It is aimed to determine the preventive effect of black seed (Nigella
sativa L; NS) and its pharmaceutically active substance volatile
fatty acid thymoquinone on relative liver weight increase in broiler
in aflatoxicosis..<p>
<b>Materials and Methods:</b> One hundred twenty 1-d-old broiler chicks
were used and divided into 6 equal groups and fed for 28 days. Animals
were received feed with 2 mg/kg total aflatoxin (AF; AFB1,
AFB2, AFG1 and AFG2), 5% black seed (NS) and 300 mg/kg thymoquinone
(TQ), according to the groups; Control, AF, NS, TQ, AF+NS
and AF+TQ. At the end of the experiment, euthanasia was performed
by decapitation after determination of the live weight of ten broiler
chickens in all groups, and systemic necropsies were performed.
The liver, the main target organ for AF, was removed and weighed
to determine relative organ weight. The relative liver weights were
calculated as % (liver weight x 100 / live body weight).<p>
<b>Results:</b> Aflatotoxin application significantly increased the relative
weight of the liver (P<0,01). While the difference was not significant
in the TQ group compared to the control group, a significant increase
in liver weight was found in the NS group. Addition of TQ to feeds
with AF significantly reduced the relative liver weight values to normal.
NS effect was found more partial compared to TQ.<p>
<b>Conclusion:</b> In conclusion, it was thought that TQ and NS prevented
the relative liver weight increase, an important biomarker for aflatoxicosis,
by probably ameliorating lipid metabolism and transport
which is impaired by the toxic effect of AF. |
|---|---|
| ISSN: | 1309-6958 2146-1953 |