Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience
The objective of this study is to explore the possibility of treating APL patients fully as outpatients. A total of 21 consecutive APL patients were identified over 30 years in the Centro de Hematología y Medicina Interna de Puebla, at Clínica Ruiz, but only 17 were studied, treated as outpatients,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2417517 |
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| author | Danae García-Vélez Moisés Manuel Gallardo-Pérez Gloria Erendy Cruz-Pérez Miranda Melgar-de-la-Paz Luis Enrique Hamilton-Avilés Paola Negrete-Rodríguez Olivia Lira-Lara Max Robles-Nasta Juan Carlos Olivares-Gazca Solón Javier Garcés-Eisele Guillermo J. Ruiz-Delgado Guillermo Jose Ruiz-Argüelles |
| author_facet | Danae García-Vélez Moisés Manuel Gallardo-Pérez Gloria Erendy Cruz-Pérez Miranda Melgar-de-la-Paz Luis Enrique Hamilton-Avilés Paola Negrete-Rodríguez Olivia Lira-Lara Max Robles-Nasta Juan Carlos Olivares-Gazca Solón Javier Garcés-Eisele Guillermo J. Ruiz-Delgado Guillermo Jose Ruiz-Argüelles |
| author_sort | Danae García-Vélez |
| collection | DOAJ |
| description | The objective of this study is to explore the possibility of treating APL patients fully as outpatients. A total of 21 consecutive APL patients were identified over 30 years in the Centro de Hematología y Medicina Interna de Puebla, at Clínica Ruiz, but only 17 were studied, treated as outpatients, and followed for at least 1 month; they were observed for median of 95 months, their median age was 27 years and all were treated with ATRA, prednisone, and adriamycin as outpatients. Treatment was completed on an outpatient basis in 15/17 cases. Molecular remission was achieved in 16/17 patients. The median follow-up was 95 months (IQR 19 - 360). The median OS and LFS were not reached, and the 12-month LFS was 94%. We have confirmed that APL can be treated entirely on an outpatient basis: this observation is of utmost relevance in a resource-limited setting, such as those prevailing in low- and middle-income countries. |
| format | Article |
| id | doaj-art-8d75f7767c284ae5b69ee5eb829a150b |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-8d75f7767c284ae5b69ee5eb829a150b2024-12-12T15:08:54ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2417517Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experienceDanae García-Vélez0Moisés Manuel Gallardo-Pérez1Gloria Erendy Cruz-Pérez2Miranda Melgar-de-la-Paz3Luis Enrique Hamilton-Avilés4Paola Negrete-Rodríguez5Olivia Lira-Lara6Max Robles-Nasta7Juan Carlos Olivares-Gazca8Solón Javier Garcés-Eisele9Guillermo J. Ruiz-Delgado10Guillermo Jose Ruiz-Argüelles11Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoFaculty of Medicine, Universidad Popular Autónoma del Estado de Puebla, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoCentro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, MéxicoThe objective of this study is to explore the possibility of treating APL patients fully as outpatients. A total of 21 consecutive APL patients were identified over 30 years in the Centro de Hematología y Medicina Interna de Puebla, at Clínica Ruiz, but only 17 were studied, treated as outpatients, and followed for at least 1 month; they were observed for median of 95 months, their median age was 27 years and all were treated with ATRA, prednisone, and adriamycin as outpatients. Treatment was completed on an outpatient basis in 15/17 cases. Molecular remission was achieved in 16/17 patients. The median follow-up was 95 months (IQR 19 - 360). The median OS and LFS were not reached, and the 12-month LFS was 94%. We have confirmed that APL can be treated entirely on an outpatient basis: this observation is of utmost relevance in a resource-limited setting, such as those prevailing in low- and middle-income countries.https://www.tandfonline.com/doi/10.1080/16078454.2024.2417517LeukemiapromyelocytictreatmentoutpatientchemotherapyATRA |
| spellingShingle | Danae García-Vélez Moisés Manuel Gallardo-Pérez Gloria Erendy Cruz-Pérez Miranda Melgar-de-la-Paz Luis Enrique Hamilton-Avilés Paola Negrete-Rodríguez Olivia Lira-Lara Max Robles-Nasta Juan Carlos Olivares-Gazca Solón Javier Garcés-Eisele Guillermo J. Ruiz-Delgado Guillermo Jose Ruiz-Argüelles Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience Hematology Leukemia promyelocytic treatment outpatient chemotherapy ATRA |
| title | Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience |
| title_full | Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience |
| title_fullStr | Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience |
| title_full_unstemmed | Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience |
| title_short | Acute promyelocytic leukemia can be fully treated on an outpatient basis: a single institution experience |
| title_sort | acute promyelocytic leukemia can be fully treated on an outpatient basis a single institution experience |
| topic | Leukemia promyelocytic treatment outpatient chemotherapy ATRA |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2417517 |
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