Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice
Conclusion: The perimenopausal period acts as a potential factor in introducing insulin resistance as evidenced by impaired insulin action and altered expression profiles of exosomal miRNAs and hepatic genes. The present study contributes to the understanding that abnormal cargos carried by plasma e...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/6251747 |
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| _version_ | 1841526358515122176 |
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| author | Yu Yang Yu Chen Changju Liu Su Wang Yijing Zhao Wen Cao Kun Wang |
| author_facet | Yu Yang Yu Chen Changju Liu Su Wang Yijing Zhao Wen Cao Kun Wang |
| author_sort | Yu Yang |
| collection | DOAJ |
| description | Conclusion: The perimenopausal period acts as a potential factor in introducing insulin resistance as evidenced by impaired insulin action and altered expression profiles of exosomal miRNAs and hepatic genes. The present study contributes to the understanding that abnormal cargos carried by plasma exosomes, such as miRNAs, may be related to altered expression of the corresponding genes in the liver and abnormal insulin response. |
| format | Article |
| id | doaj-art-8d71fb2850b44722bc7532fd6474a288 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-8d71fb2850b44722bc7532fd6474a2882025-01-17T00:00:03ZengWileyJournal of Diabetes Research2314-67532025-01-01202510.1155/jdr/6251747Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal MiceYu Yang0Yu Chen1Changju Liu2Su Wang3Yijing Zhao4Wen Cao5Kun Wang6Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyConclusion: The perimenopausal period acts as a potential factor in introducing insulin resistance as evidenced by impaired insulin action and altered expression profiles of exosomal miRNAs and hepatic genes. The present study contributes to the understanding that abnormal cargos carried by plasma exosomes, such as miRNAs, may be related to altered expression of the corresponding genes in the liver and abnormal insulin response.http://dx.doi.org/10.1155/jdr/6251747 |
| spellingShingle | Yu Yang Yu Chen Changju Liu Su Wang Yijing Zhao Wen Cao Kun Wang Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice Journal of Diabetes Research |
| title | Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice |
| title_full | Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice |
| title_fullStr | Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice |
| title_full_unstemmed | Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice |
| title_short | Analysis of Exosomal miRNA and Hepatic mRNA Expression in the Dysregulation of Insulin Action in Perimenopausal Mice |
| title_sort | analysis of exosomal mirna and hepatic mrna expression in the dysregulation of insulin action in perimenopausal mice |
| url | http://dx.doi.org/10.1155/jdr/6251747 |
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