HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children.

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children.

Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression. In many diseases including murine malaria, HO-1 induction produces protective anti...

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Main Authors: Michael Walther, Adam De Caul, Peter Aka, Madi Njie, Alfred Amambua-Ngwa, Brigitte Walther, Irene M Predazzi, Aubrey Cunnington, Susanne Deininger, Ebako N Takem, Augustine Ebonyi, Sebastian Weis, Robert Walton, Sarah Rowland-Jones, Giorgio Sirugo, Scott M Williams, David J Conway
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002579&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002579&type=printable

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