SPRTN metalloprotease participates in repair of ROS-mediated DNA-protein crosslinks

SPRTN metalloprotease participates in repair of ROS-mediated DNA-protein crosslinks

Abstract Exposure to reactive oxygen species (ROS) can induce DNA-protein crosslinks (DPCs), unusually bulky DNA lesions that block replication and transcription and play a role in aging, cancer, cardiovascular disease, and neurodegenerative disorders. Repair of DPCs depends on the coordinated effor...

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Bibliographic Details
Main Authors: Luke Erber, Arnold S. Groehler, Cesar I. Cyuzuzo, Jahan Baker-Wainwright, Reeja S. Maskey, Lei Li, Yuichi J. Machida, Natalia Tretyakova
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-81799-9
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