TRIM23 mediates cGAS-induced autophagy in anti-HSV defense

TRIM23 mediates cGAS-induced autophagy in anti-HSV defense

Abstract The cGAS-STING pathway, well-known to elicit interferon (IFN) responses, is also a key inducer of autophagy upon virus infection or other stimuli. Whereas the mediators for cGAS-induced IFN responses are well characterized, much less is known about how cGAS elicits autophagy. Here, we repor...

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Main Authors: Dhiraj Acharya, Zuberwasim Sayyad, Helene Hoenigsperger, Maximilian Hirschenberger, Matthew Zurenski, Kannan Balakrishnan, Junji Zhu, Sebastian Gableske, Jiro Kato, Shen-Ying Zhang, Jean-Laurent Casanova, Joel Moss, Konstantin M. J. Sparrer, Michaela U. Gack
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59338-5
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https://doi.org/10.1038/s41467-025-59338-5

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