Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect
Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1495393/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841540131634282496 |
|---|---|
| author | Yuhan Wang Junsha An Jianbo Zhou Liming Chang Quan Zhang Quan Zhang Quan Zhang Fu Peng |
| author_facet | Yuhan Wang Junsha An Jianbo Zhou Liming Chang Quan Zhang Quan Zhang Quan Zhang Fu Peng |
| author_sort | Yuhan Wang |
| collection | DOAJ |
| description | Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in the physicochemical properties and sources, pharmacological effects and mechanisms, pharmacokinetic progress, and safety of HSYA, focusing on the involvement of HSYA in the regulation of related pathways and mechanisms of apoptosis, autophagy, and the tumor immune microenvironment in a variety of cancers. This can serve as a theoretical basis for further research and development of HSYA, with insights into the mechanisms of anticancer signaling pathways. |
| format | Article |
| id | doaj-art-8cfa2f0ac53c4feab4eb54095be3d7d4 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-8cfa2f0ac53c4feab4eb54095be3d7d42025-01-14T06:10:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14953931495393Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effectYuhan Wang0Junsha An1Jianbo Zhou2Liming Chang3Quan Zhang4Quan Zhang5Quan Zhang6Fu Peng7Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, ChinaSichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, School of Pharmacy, Chengdu Medical College, Institute of Materia Medica, Chengdu, ChinaDevelopment and Regeneration Key Lab of Sichuan Province, Department of Pathology, Chengdu Medical College, Chengdu, ChinaDevelopment and Regeneration Key Lab of Sichuan Province, Department of Anatomy and Histology and Embryology, Chengdu Medical College, Chengdu, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Department of Pharmacy, West China Hospital, Chengdu, ChinaHydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atherosclerosis, cancer, and diabetes. However, no study has reported on the anticancer mechanisms of Hydroxysafflor yellow A (HSYA), a principal bioactive compound in safflower. This review discusses recent developments in the physicochemical properties and sources, pharmacological effects and mechanisms, pharmacokinetic progress, and safety of HSYA, focusing on the involvement of HSYA in the regulation of related pathways and mechanisms of apoptosis, autophagy, and the tumor immune microenvironment in a variety of cancers. This can serve as a theoretical basis for further research and development of HSYA, with insights into the mechanisms of anticancer signaling pathways.https://www.frontiersin.org/articles/10.3389/fphar.2024.1495393/fullhydroxysafflor yellow Apharmacological effectsanticancer effectpharmacokinetic progresssafety |
| spellingShingle | Yuhan Wang Junsha An Jianbo Zhou Liming Chang Quan Zhang Quan Zhang Quan Zhang Fu Peng Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect Frontiers in Pharmacology hydroxysafflor yellow A pharmacological effects anticancer effect pharmacokinetic progress safety |
| title | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect |
| title_full | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect |
| title_fullStr | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect |
| title_full_unstemmed | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect |
| title_short | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect |
| title_sort | hydroxysafflor yellow a a natural pigment with potential anticancer therapeutic effect |
| topic | hydroxysafflor yellow A pharmacological effects anticancer effect pharmacokinetic progress safety |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1495393/full |
| work_keys_str_mv | AT yuhanwang hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT junshaan hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT jianbozhou hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT limingchang hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT quanzhang hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT quanzhang hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT quanzhang hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect AT fupeng hydroxysaffloryellowaanaturalpigmentwithpotentialanticancertherapeuticeffect |