Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types
Abstract Cancer is a complex disease with profound societal and economic impacts, especially in metastatic cases where treatment challenges arise due to the absence of reliable biomarkers and effective therapies. While P21‐activated kinases (PAKs) play a key role in cancer progression, their potenti...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70192 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527525455429632 |
|---|---|
| author | Jessie M. Vo Linh M. La Ananda V. Anderson Abdulaziz H. Alanazi Payaningal R. Somanath |
| author_facet | Jessie M. Vo Linh M. La Ananda V. Anderson Abdulaziz H. Alanazi Payaningal R. Somanath |
| author_sort | Jessie M. Vo |
| collection | DOAJ |
| description | Abstract Cancer is a complex disease with profound societal and economic impacts, especially in metastatic cases where treatment challenges arise due to the absence of reliable biomarkers and effective therapies. While P21‐activated kinases (PAKs) play a key role in cancer progression, their potential as predictive markers for metastasis and therapeutic targets has not been fully explored. We hypothesized that genetic alterations in PAK isoforms could be linked to reduced overall patient survival. To investigate this, we used data from the cBioPortal for Cancer Genomics, analyzing several randomized, multicentered phase‐3 clinical trial datasets. The analysis revealed significant genetic alterations in PAK genes, particularly in cancers such as breast, prostate, pancreatic, and lung. Notably, elevated PAK expression was associated with poorer survival outcomes in prostate and breast cancer patients. In pancreatic and lung cancers, although a trend of poorer survival with PAK alterations was observed, it was not statistically significant. Our findings underscore the importance of PAK isoforms as potential biomarkers and therapeutic targets, particularly in metastatic cancers. Further research could lead to improved patient outcomes through targeted interventions aimed at PAK‐related pathways, with PAK serving as a reliable biomarker for the precise diagnosis, monitoring, and personalization of treatment strategies. |
| format | Article |
| id | doaj-art-8ce84062345a41fb9066518a69c423e5 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-8ce84062345a41fb9066518a69c423e52025-01-15T13:36:31ZengWileyPhysiological Reports2051-817X2025-01-01131n/an/a10.14814/phy2.70192Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer typesJessie M. Vo0Linh M. La1Ananda V. Anderson2Abdulaziz H. Alanazi3Payaningal R. Somanath4Clinical and Experimental Therapeutics University of Georgia Augusta Georgia USAClinical and Experimental Therapeutics University of Georgia Augusta Georgia USAClinical and Experimental Therapeutics University of Georgia Augusta Georgia USAClinical and Experimental Therapeutics University of Georgia Augusta Georgia USAClinical and Experimental Therapeutics University of Georgia Augusta Georgia USAAbstract Cancer is a complex disease with profound societal and economic impacts, especially in metastatic cases where treatment challenges arise due to the absence of reliable biomarkers and effective therapies. While P21‐activated kinases (PAKs) play a key role in cancer progression, their potential as predictive markers for metastasis and therapeutic targets has not been fully explored. We hypothesized that genetic alterations in PAK isoforms could be linked to reduced overall patient survival. To investigate this, we used data from the cBioPortal for Cancer Genomics, analyzing several randomized, multicentered phase‐3 clinical trial datasets. The analysis revealed significant genetic alterations in PAK genes, particularly in cancers such as breast, prostate, pancreatic, and lung. Notably, elevated PAK expression was associated with poorer survival outcomes in prostate and breast cancer patients. In pancreatic and lung cancers, although a trend of poorer survival with PAK alterations was observed, it was not statistically significant. Our findings underscore the importance of PAK isoforms as potential biomarkers and therapeutic targets, particularly in metastatic cancers. Further research could lead to improved patient outcomes through targeted interventions aimed at PAK‐related pathways, with PAK serving as a reliable biomarker for the precise diagnosis, monitoring, and personalization of treatment strategies.https://doi.org/10.14814/phy2.70192cancergenetic alterationsmetastasisP21 activated kinasepatient survival |
| spellingShingle | Jessie M. Vo Linh M. La Ananda V. Anderson Abdulaziz H. Alanazi Payaningal R. Somanath Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types Physiological Reports cancer genetic alterations metastasis P21 activated kinase patient survival |
| title | Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types |
| title_full | Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types |
| title_fullStr | Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types |
| title_full_unstemmed | Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types |
| title_short | Genome analysis uncovers an inverse correlation between alterations in P21‐activated kinases and patient survival across multiple cancer types |
| title_sort | genome analysis uncovers an inverse correlation between alterations in p21 activated kinases and patient survival across multiple cancer types |
| topic | cancer genetic alterations metastasis P21 activated kinase patient survival |
| url | https://doi.org/10.14814/phy2.70192 |
| work_keys_str_mv | AT jessiemvo genomeanalysisuncoversaninversecorrelationbetweenalterationsinp21activatedkinasesandpatientsurvivalacrossmultiplecancertypes AT linhmla genomeanalysisuncoversaninversecorrelationbetweenalterationsinp21activatedkinasesandpatientsurvivalacrossmultiplecancertypes AT anandavanderson genomeanalysisuncoversaninversecorrelationbetweenalterationsinp21activatedkinasesandpatientsurvivalacrossmultiplecancertypes AT abdulazizhalanazi genomeanalysisuncoversaninversecorrelationbetweenalterationsinp21activatedkinasesandpatientsurvivalacrossmultiplecancertypes AT payaningalrsomanath genomeanalysisuncoversaninversecorrelationbetweenalterationsinp21activatedkinasesandpatientsurvivalacrossmultiplecancertypes |