Importance of fasting serum glucose, haemoglobin a1c and fructosamine in the diagnosis of diabetes
<b>Aim:</b> The primary aim of this study was to evaluate the changes in hematological and certain biochemical parameters in the diagnosis of rabbits with experimental diabetes mellitus induced with two different doses of alloxan monohydrate (100 and 175 mg/kg). The secondary aim of this...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=541 |
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| Summary: | <b>Aim:</b> The primary aim of this study was to evaluate the
changes in hematological and certain biochemical parameters
in the diagnosis of rabbits with experimental diabetes
mellitus induced with two different doses of alloxan monohydrate
(100 and 175 mg/kg). The secondary aim of this
study was to determine the importance of glucose, haemoglobin
A1c and fructosamine in the diagnosis of the disease.<p>
<b>Materials and Methods:</b> Rabbits were randomly allocated
to two groups. The first group included 12 rabbits and the
second group included 13 rabbits. Hundred and 175 mg/
kg dose of the alloxan solutions were given intravenously to
the first group and second group, respectively. White blood
cell, red blood cell, haemoglobin, platelet counts, paced cell
volume, mean corpuscular haemoglobin concentration and
mean corpuscular volume values were determined. Fasting
serum glucose, fructosamine, insulin, haemoglobin HbA1c,
total cholesterol, triglyceride, urea, aspartate amino transferase
and alanin amino transferase levels were measured.<p>
<b>Results:</b> Statistically significantly increases of serum fasting
glucose, fructosamine, haemoglobin A1c, total cholesterol
and triglyceride concentrations and decreases of
serum insulin levels and red blood cell, paced cell volume
and haemoglobin values were determined (p<0.05) in both
groups.<p>
<b>Conclusion:</b> Fasting serum glucose, fructosamine and haemoglobin
A1c could be more important indicators for the
diagnosis of diabetes mellitus. |
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| ISSN: | 1309-6958 2146-1953 |