Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study
Objectives To assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population cohort.Design Population-based matched cohort study.Setting All...
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e037080.full |
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| author | Henrik Toft Sørensen Kasper Adelborg Péter Szentkúti Jens Sundbøll Szimonetta Komjáthiné Szépligeti Hans Gregersen |
| author_facet | Henrik Toft Sørensen Kasper Adelborg Péter Szentkúti Jens Sundbøll Szimonetta Komjáthiné Szépligeti Hans Gregersen |
| author_sort | Henrik Toft Sørensen |
| collection | DOAJ |
| description | Objectives To assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population cohort.Design Population-based matched cohort study.Setting All Danish hospitals and hospital outpatient clinics from 2004 to 2013.Participants Patients with a constipation diagnosis matched on age, sex and calendar year to 10 individuals without constipation from the general population.Main outcomes measures Comorbidity-adjusted and medication-adjusted hazard ratios (aHRs) for cardiovascular outcomes based on Cox regression analysis.Results 83 239 patients with constipation were matched to 832 384 individuals without constipation. The median age at constipation diagnosis was 46.5% and 41% were men. Constipation was strongly associated with venous thromboembolism (aHR 2.04, 95% CI 1.89 to 2.20), especially splanchnic venous thrombosis (4.23, 95% CI 2.45 to 7.31). Constipation was also associated with arterial events, including myocardial infarction (1.24, 95% CI 1.14 to 1.35), ischaemic stroke (1.50, 95% CI 1.41 to 1.60), haemorrhagic stroke (1.46, 95% CI 1.26 to 1.69), peripheral artery disease (1.34, 95% CI 1.20 to 1.50), atrial fibrillation or atrial flutter (1.27, 95% CI 1.20 to 1.34) and heart failure (1.52, 95% CI 1.42 to 1.62). The associations were strongest during the first year after the constipation diagnosis and strengthened with an increased number of laxative prescriptions.Conclusions Constipation was associated with an increased risk of several cardiovascular diseases, in particular venous thromboembolism. |
| format | Article |
| id | doaj-art-8cd3d7cd9d1046b9b5e3f20bdbf981b4 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-8cd3d7cd9d1046b9b5e3f20bdbf981b42025-01-08T03:05:08ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2020-037080Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort studyHenrik Toft Sørensen0Kasper Adelborg1Péter Szentkúti2Jens Sundbøll3Szimonetta Komjáthiné Szépligeti4Hans Gregersen5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark1 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Clinical Epidemiology, Aarhus Universitetshospital, Aarhus, DenmarkDepartment of Clinical Epidemiology, Aarhus Universitetshospital, Aarhus, Denmark1 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark2 GIOME, Department of Surgery, Chinese University of Hong Kong, Shatin, Hong KongObjectives To assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population cohort.Design Population-based matched cohort study.Setting All Danish hospitals and hospital outpatient clinics from 2004 to 2013.Participants Patients with a constipation diagnosis matched on age, sex and calendar year to 10 individuals without constipation from the general population.Main outcomes measures Comorbidity-adjusted and medication-adjusted hazard ratios (aHRs) for cardiovascular outcomes based on Cox regression analysis.Results 83 239 patients with constipation were matched to 832 384 individuals without constipation. The median age at constipation diagnosis was 46.5% and 41% were men. Constipation was strongly associated with venous thromboembolism (aHR 2.04, 95% CI 1.89 to 2.20), especially splanchnic venous thrombosis (4.23, 95% CI 2.45 to 7.31). Constipation was also associated with arterial events, including myocardial infarction (1.24, 95% CI 1.14 to 1.35), ischaemic stroke (1.50, 95% CI 1.41 to 1.60), haemorrhagic stroke (1.46, 95% CI 1.26 to 1.69), peripheral artery disease (1.34, 95% CI 1.20 to 1.50), atrial fibrillation or atrial flutter (1.27, 95% CI 1.20 to 1.34) and heart failure (1.52, 95% CI 1.42 to 1.62). The associations were strongest during the first year after the constipation diagnosis and strengthened with an increased number of laxative prescriptions.Conclusions Constipation was associated with an increased risk of several cardiovascular diseases, in particular venous thromboembolism.https://bmjopen.bmj.com/content/10/9/e037080.full |
| spellingShingle | Henrik Toft Sørensen Kasper Adelborg Péter Szentkúti Jens Sundbøll Szimonetta Komjáthiné Szépligeti Hans Gregersen Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study BMJ Open |
| title | Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study |
| title_full | Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study |
| title_fullStr | Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study |
| title_full_unstemmed | Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study |
| title_short | Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study |
| title_sort | constipation and risk of cardiovascular diseases a danish population based matched cohort study |
| url | https://bmjopen.bmj.com/content/10/9/e037080.full |
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