Inhibition of ATM enhances the immunogenicity of triple-negative breast cancer by promoting MHC-I expression

Inhibition of ATM enhances the immunogenicity of triple-negative breast cancer by promoting MHC-I expression

Abstract The immunotherapy has achieved some efficacy in triple-negative breast cancer (TNBC), but the benefit population is limited, primarily due to an abnormal immune microenvironment. Thus, it is necessary to explore new molecular targets to enhance the immunogenicity of TNBC cells and improve t...

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Main Authors: Jiazhen Li, Chenying Liu, Xiaolong Qian, Xiaozi Wang, Hui Sun, Lu Wang, Huiqin Xue, Yuanming Song, Jiamei Liu, Yafang Zhao, Yumian Jia, Fengxia Qin, Tianhua Zhang, Xiaojing Guo
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07944-y
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