Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study

Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study

Background/objectivesAutism spectrum disorder (ASD) is associated with excitatory-inhibitory imbalance and oxidative stress. GABA, an inhibitory neurotransmitter, and related nutritional therapies are promising in restoring these imbalances. GABAergic deficits and glutamate excitotoxicity are two es...

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Bibliographic Details
Main Authors:	Altaf N. Alabdali, Abir Ben Bacha, Mona Alonazi, Sameera Abuaish, Ahmad Almotairi, Laila Al-Ayadhi, Afaf K. El-Ansary
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	autism spectrum disorder excitatory-inhibitory balance oxidative stress EAAT2 KCC2 NKCC1
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2025.1553438/full
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