Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study

Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study

Background/objectivesAutism spectrum disorder (ASD) is associated with excitatory-inhibitory imbalance and oxidative stress. GABA, an inhibitory neurotransmitter, and related nutritional therapies are promising in restoring these imbalances. GABAergic deficits and glutamate excitotoxicity are two es...

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Bibliographic Details
Main Authors: Altaf N. Alabdali, Abir Ben Bacha, Mona Alonazi, Sameera Abuaish, Ahmad Almotairi, Laila Al-Ayadhi, Afaf K. El-Ansary
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorder
excitatory-inhibitory balance
oxidative stress
EAAT2
KCC2
NKCC1
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1553438/full
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https://www.frontiersin.org/articles/10.3389/fnmol.2025.1553438/full

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