Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus)
Skin, as the largest organ in the human and animal body, serves as the main protection against various external factors such as sharp objects, extreme temperatures, chemicals, or physical trauma. This study aims to evaluate the effectiveness of seaweed (Ulva lactuca) extract-based hydrogel in accele...
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2024-12-01
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| Series: | Jurnal Teknologi Laboratorium |
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| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/536 |
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| author | Stephanie Taniwan Refi Ikhtiari Stephanie Taniwan Fiska Maya Wardhani |
| author_facet | Stephanie Taniwan Refi Ikhtiari Stephanie Taniwan Fiska Maya Wardhani |
| author_sort | Stephanie Taniwan |
| collection | DOAJ |
| description | Skin, as the largest organ in the human and animal body, serves as the main protection against various external factors such as sharp objects, extreme temperatures, chemicals, or physical trauma. This study aims to evaluate the effectiveness of seaweed (Ulva lactuca) extract-based hydrogel in accelerating incision wound healing in Rattus norvegicus rats. This experimental study used a post-test only controlled group design with six treatment groups: Ulva lactuca hydrogel 5%, 10%, 15%, positive control (Bioplasenton), negative control (wound without treatment), and rat group without treatment. Data were analyzed using ANOVA test. The results showed that Ulva lactuca hydrogel 5% gave the best results in accelerating wound healing. The wound diameter in the 5% group decreased significantly, from 15.3 cm on day 0 to 10.9 cm on day 3, 4.7 cm on day 6, and 2.36 cm on day 14. Histopathology results showed increased epithelialization, decreased inflammation, and increased collagen deposition in the 5% group compared with the control group. Quantitatively, the 5% hydrogel group achieved wound healing up to 30% faster than the positive control and 50% faster than the negative control. The 5% Ulva lactuca hydrogel proved to be most effective in accelerating wound healing by modulating inflammation and promoting tissue regeneration. This concentration provides an optimal balance between efficacy and safety, making it a potential alternative for wound therapy. |
| format | Article |
| id | doaj-art-8cc55161c37d49f59e39fbf241e8a222 |
| institution | Kabale University |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| publishDate | 2024-12-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj-art-8cc55161c37d49f59e39fbf241e8a2222025-01-03T15:40:12ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912024-12-0113217418510.29238/teknolabjournal.v13i2.536488Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus)Stephanie Taniwan0Refi Ikhtiari1Stephanie Taniwan2Fiska Maya Wardhani3Universitas Prima IndonesiaUniversitas Prima IndonesiaUniversitas Prima IndonesiaUniversitas Prima IndonesiaSkin, as the largest organ in the human and animal body, serves as the main protection against various external factors such as sharp objects, extreme temperatures, chemicals, or physical trauma. This study aims to evaluate the effectiveness of seaweed (Ulva lactuca) extract-based hydrogel in accelerating incision wound healing in Rattus norvegicus rats. This experimental study used a post-test only controlled group design with six treatment groups: Ulva lactuca hydrogel 5%, 10%, 15%, positive control (Bioplasenton), negative control (wound without treatment), and rat group without treatment. Data were analyzed using ANOVA test. The results showed that Ulva lactuca hydrogel 5% gave the best results in accelerating wound healing. The wound diameter in the 5% group decreased significantly, from 15.3 cm on day 0 to 10.9 cm on day 3, 4.7 cm on day 6, and 2.36 cm on day 14. Histopathology results showed increased epithelialization, decreased inflammation, and increased collagen deposition in the 5% group compared with the control group. Quantitatively, the 5% hydrogel group achieved wound healing up to 30% faster than the positive control and 50% faster than the negative control. The 5% Ulva lactuca hydrogel proved to be most effective in accelerating wound healing by modulating inflammation and promoting tissue regeneration. This concentration provides an optimal balance between efficacy and safety, making it a potential alternative for wound therapy.https://teknolabjournal.com/index.php/Jtl/article/view/536skin histopathologyhydrogelulva lactucacut wounds |
| spellingShingle | Stephanie Taniwan Refi Ikhtiari Stephanie Taniwan Fiska Maya Wardhani Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) Jurnal Teknologi Laboratorium skin histopathology hydrogel ulva lactuca cut wounds |
| title | Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) |
| title_full | Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) |
| title_fullStr | Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) |
| title_full_unstemmed | Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) |
| title_short | Evaluation of hydrogel formulated with seaweed extract (Ulva lactuca) for incised wound healing in white rats (Rattus norvegicus) |
| title_sort | evaluation of hydrogel formulated with seaweed extract ulva lactuca for incised wound healing in white rats rattus norvegicus |
| topic | skin histopathology hydrogel ulva lactuca cut wounds |
| url | https://teknolabjournal.com/index.php/Jtl/article/view/536 |
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