Meprin β activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury

Meprin β activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury

Abstract Background Inflammation plays a central role in the progression of kidney injury induced by ischemia/reperfusion (IR). Meprin metalloproteinases have been implicated in the pathophysiology of IR-induced kidney injury. Existing data from in vitro and in vivo studies show that meprins modulat...

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Bibliographic Details
Main Authors: Shaymaa Abousaad, Faihaa Ahmed, Ayman Abouzeid, Christine Adhiambo, Elimelda Moige Ongeri
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Nephrology
Subjects:
Interleukin-6
Proliferation
Ischemia-reperfusion
Meprin metalloprotease β
Online Access:https://doi.org/10.1186/s12882-025-04224-x
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