Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity
Objective To evaluate the efficacy and safety of selective posterior rhizotomy (SPR) for the treatment of pure hereditary spastic paraplegia (PHSP) ⁃ associated lower limb spasticity. Methods Nine patients with PHSP were admitted to Union Hospital, Tongji Medical College, Huazhong University of Scie...
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Tianjin Huanhu Hospital
2024-12-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2966 |
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| author | TANG Nan SHEN Yin WANG Lei ZHENG Jiang‐lin HUANG Ning ZHOU Ying‐chun |
| author_facet | TANG Nan SHEN Yin WANG Lei ZHENG Jiang‐lin HUANG Ning ZHOU Ying‐chun |
| author_sort | TANG Nan |
| collection | DOAJ |
| description | Objective To evaluate the efficacy and safety of selective posterior rhizotomy (SPR) for the treatment of pure hereditary spastic paraplegia (PHSP) ⁃ associated lower limb spasticity. Methods Nine patients with PHSP were admitted to Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2021 to February 2023. The Ashworth Scale (AS) score of hip adductors, quadriceps femoris, triceps surae and hamstring, femoral angle, popliteal fossa angle and dorsiflexion angle of foot, and Gross Motor Function Classification System (GMFCS) score before and after surgery were analyzed. Postoperative complications were recorded. Results All 9 patients completed SPR. No serious complication was observed. The AS score before and after surgery were significantly different of hip adductors (F = 43.568, P = 0.000), quadriceps femoris (F = 43.000, P = 0.000), triceps surae (F = 59.200, P = 0.000) and hamstring (F = 116.138, P = 0.000). The AS score of hip adductors (P = 0.000, 0.000), quadriceps femoris (P = 0.000, 0.000), triceps surae (P = 0.000, 0.000) and hamstring (P = 0.000, 0.000) 1 d and 12 months after surgery were significantly decreased comparing with those before surgery. The femoral angle (t = ⁃ 17.812, P = 0.000) and popliteal angle (t = ⁃ 12.791, P = 0.000) 5 d after the surgery were significantly increased comparing with those before surgery, while the dorsiflexion angle of foot 5 d after surgery was significantly decreased comparing with that before surgery (t = 14.050, P = 0.000). The GMFCS score before and 12 months after surgery were no significantly different (t = 1.000, P = 0.347). Conclusions SPR has good efficacy and safety for the treatment of PHSP⁃associated lower limb spasticity. |
| format | Article |
| id | doaj-art-8c800074e9764afe84e2032d691c2a5b |
| institution | Kabale University |
| issn | 1672-6731 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj-art-8c800074e9764afe84e2032d691c2a5b2025-01-14T12:42:01ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312024-12-0124121016102010.3969/j.issn.1672⁃6731.2024.12.007Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticityTANG Nan0SHEN Yin1WANG Lei2ZHENG Jiang‐lin3HUANG Ning4ZHOU Ying‐chun5Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, ChinaDepartment of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, ChinaObjective To evaluate the efficacy and safety of selective posterior rhizotomy (SPR) for the treatment of pure hereditary spastic paraplegia (PHSP) ⁃ associated lower limb spasticity. Methods Nine patients with PHSP were admitted to Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2021 to February 2023. The Ashworth Scale (AS) score of hip adductors, quadriceps femoris, triceps surae and hamstring, femoral angle, popliteal fossa angle and dorsiflexion angle of foot, and Gross Motor Function Classification System (GMFCS) score before and after surgery were analyzed. Postoperative complications were recorded. Results All 9 patients completed SPR. No serious complication was observed. The AS score before and after surgery were significantly different of hip adductors (F = 43.568, P = 0.000), quadriceps femoris (F = 43.000, P = 0.000), triceps surae (F = 59.200, P = 0.000) and hamstring (F = 116.138, P = 0.000). The AS score of hip adductors (P = 0.000, 0.000), quadriceps femoris (P = 0.000, 0.000), triceps surae (P = 0.000, 0.000) and hamstring (P = 0.000, 0.000) 1 d and 12 months after surgery were significantly decreased comparing with those before surgery. The femoral angle (t = ⁃ 17.812, P = 0.000) and popliteal angle (t = ⁃ 12.791, P = 0.000) 5 d after the surgery were significantly increased comparing with those before surgery, while the dorsiflexion angle of foot 5 d after surgery was significantly decreased comparing with that before surgery (t = 14.050, P = 0.000). The GMFCS score before and 12 months after surgery were no significantly different (t = 1.000, P = 0.347). Conclusions SPR has good efficacy and safety for the treatment of PHSP⁃associated lower limb spasticity.http://www.cjcnn.org/index.php/cjcnn/article/view/2966spastic paraplegia，hereditaryspasmlower extremityrhizotomyneurophysiological monitoring |
| spellingShingle | TANG Nan SHEN Yin WANG Lei ZHENG Jiang‐lin HUANG Ning ZHOU Ying‐chun Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity Chinese Journal of Contemporary Neurology and Neurosurgery spastic paraplegia，hereditary spasm lower extremity rhizotomy neurophysiological monitoring |
| title | Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity |
| title_full | Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity |
| title_fullStr | Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity |
| title_full_unstemmed | Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity |
| title_short | Selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity |
| title_sort | selective posterior rhizotomy for the treatment of pure hereditary spastic paraplegia⁃ associated lower limb spasticity |
| topic | spastic paraplegia，hereditary spasm lower extremity rhizotomy neurophysiological monitoring |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2966 |
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