Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process
Wound healing is a multicellular and complicated process that strives to restore the skin’s barrier function. Different cell types, including keratinocytes, endothelial cells and fibroblasts collaborate for the process to complete. Tridax procumbens is a very important natural plant that is commonly...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1387_24 |
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| author | M. Jeevitha Kaarthikeyan Gurumoorthy M. Navarasu |
| author_facet | M. Jeevitha Kaarthikeyan Gurumoorthy M. Navarasu |
| author_sort | M. Jeevitha |
| collection | DOAJ |
| description | Wound healing is a multicellular and complicated process that strives to restore the skin’s barrier function. Different cell types, including keratinocytes, endothelial cells and fibroblasts collaborate for the process to complete. Tridax procumbens is a very important natural plant that is commonly found in the tropical region and has a wide range of pharmacological actions. In the present study the molecular docking was used to identify the activity of four compounds from T. procumbens to the selected receptor. The goal of this work was to anticipate the capacity of four T. procumbens compounds to interact with IL-1, IL-6, and TNF-α. Pyrx was used to run docking simulations for these compounds. Results of this study showed that all the four compounds showed interaction with selected target proteins. Among the four compounds, Tannic acid showed excellent binding and hydrogen bond interaction with all the selected target proteins. The results showed that T. procumbens compounds are effective anti-inflammatory agents. However, further research is required to validate the action of these molecules. |
| format | Article |
| id | doaj-art-8c6836cd037d4d3ebbea165292b3c116 |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-8c6836cd037d4d3ebbea165292b3c1162025-01-13T11:00:09ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S4056S405910.4103/jpbs.jpbs_1387_24Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing ProcessM. JeevithaKaarthikeyan GurumoorthyM. NavarasuWound healing is a multicellular and complicated process that strives to restore the skin’s barrier function. Different cell types, including keratinocytes, endothelial cells and fibroblasts collaborate for the process to complete. Tridax procumbens is a very important natural plant that is commonly found in the tropical region and has a wide range of pharmacological actions. In the present study the molecular docking was used to identify the activity of four compounds from T. procumbens to the selected receptor. The goal of this work was to anticipate the capacity of four T. procumbens compounds to interact with IL-1, IL-6, and TNF-α. Pyrx was used to run docking simulations for these compounds. Results of this study showed that all the four compounds showed interaction with selected target proteins. Among the four compounds, Tannic acid showed excellent binding and hydrogen bond interaction with all the selected target proteins. The results showed that T. procumbens compounds are effective anti-inflammatory agents. However, further research is required to validate the action of these molecules.https://journals.lww.com/10.4103/jpbs.jpbs_1387_24innovativemolecular dockingtridax procumbenswound healing |
| spellingShingle | M. Jeevitha Kaarthikeyan Gurumoorthy M. Navarasu Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process Journal of Pharmacy and Bioallied Sciences innovative molecular docking tridax procumbens wound healing |
| title | Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process |
| title_full | Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process |
| title_fullStr | Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process |
| title_full_unstemmed | Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process |
| title_short | Computational Evaluation of Tridax Procumbens Phytoconstituents in Wound Healing Process |
| title_sort | computational evaluation of tridax procumbens phytoconstituents in wound healing process |
| topic | innovative molecular docking tridax procumbens wound healing |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1387_24 |
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