Salivary cardiac troponin does not correlate with serum levels
IntroductionSeveral studies suggest a potential correlation between troponin levels detected in serum and saliva. However, prior investigations have not adequately addressed the critical aspect of collecting samples upon admission, which is essential for timely troponin level determination. This stu...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1440138/full |
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| author | Hoa Tran Vu Hoang Vu Quang Dang Duy Pham Duc Minh Tran Suong Thi Bang Nguyen Vien Thanh Truong Binh Quang Truong |
| author_facet | Hoa Tran Vu Hoang Vu Quang Dang Duy Pham Duc Minh Tran Suong Thi Bang Nguyen Vien Thanh Truong Binh Quang Truong |
| author_sort | Hoa Tran |
| collection | DOAJ |
| description | IntroductionSeveral studies suggest a potential correlation between troponin levels detected in serum and saliva. However, prior investigations have not adequately addressed the critical aspect of collecting samples upon admission, which is essential for timely troponin level determination. This study aimed to evaluate the relationship between troponin levels in serum and saliva among patients admitted for chest pain evaluation.MethodsThis observational study was conducted at the Interventional Cardiology Department of the University Medical Center HCMC. Patients presenting with chest pain were enrolled, and unstimulated saliva samples were collected using the Navazesh method simultaneously with the initial blood collection. These samples were then analyzed for levels of salivary troponin I, serum troponin I, and serum high-sensitive troponin T.ResultsAmong the 48 patients included, 22 (46%) exhibited myocardial injury, while 12 (25%) were diagnosed with acute myocardial infarction. No significant difference was observed in salivary troponin I levels between the non-myocardial injury and myocardial injury groups (p = 0.425). Moreover, no correlation was found between salivary troponin I levels and either serum troponin T or serum troponin I levels (Pearson correlation p = 0.761, 0.500; Spearman correlation p = 0.857, 0.136, respectively). The ROC curve for salivary troponin I in predicting myocardial injury displayed an AUC of 0.566 (95% CI: 0.402–0.731), indicating poor discriminatory power.ConclusionsIn our investigation, salivary troponin I failed to demonstrate a meaningful correlation with serum troponins, thereby limiting its practical utility in diagnosing myocardial injury or myocardial infarction. Further research is warranted to explore its diagnostic reliability and clinical applicability. |
| format | Article |
| id | doaj-art-8c4e193b50b54f6ca7ffed1d05705804 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-8c4e193b50b54f6ca7ffed1d057058042025-01-07T06:45:45ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011110.3389/fcvm.2024.14401381440138Salivary cardiac troponin does not correlate with serum levelsHoa Tran0Vu Hoang Vu1Quang Dang Duy Pham2Duc Minh Tran3Suong Thi Bang Nguyen4Vien Thanh Truong5Binh Quang Truong6Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamInterventional Cardiology Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamInterventional Cardiology Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamLaboratory Department, University Medical Center Ho Chi Minh City, Ho Chi Minh City, VietnamDepartment of Cardiology, The Christ Hospital Health Network, Lindner Research Center, Cincinnati, OH, United StatesFaculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, VietnamIntroductionSeveral studies suggest a potential correlation between troponin levels detected in serum and saliva. However, prior investigations have not adequately addressed the critical aspect of collecting samples upon admission, which is essential for timely troponin level determination. This study aimed to evaluate the relationship between troponin levels in serum and saliva among patients admitted for chest pain evaluation.MethodsThis observational study was conducted at the Interventional Cardiology Department of the University Medical Center HCMC. Patients presenting with chest pain were enrolled, and unstimulated saliva samples were collected using the Navazesh method simultaneously with the initial blood collection. These samples were then analyzed for levels of salivary troponin I, serum troponin I, and serum high-sensitive troponin T.ResultsAmong the 48 patients included, 22 (46%) exhibited myocardial injury, while 12 (25%) were diagnosed with acute myocardial infarction. No significant difference was observed in salivary troponin I levels between the non-myocardial injury and myocardial injury groups (p = 0.425). Moreover, no correlation was found between salivary troponin I levels and either serum troponin T or serum troponin I levels (Pearson correlation p = 0.761, 0.500; Spearman correlation p = 0.857, 0.136, respectively). The ROC curve for salivary troponin I in predicting myocardial injury displayed an AUC of 0.566 (95% CI: 0.402–0.731), indicating poor discriminatory power.ConclusionsIn our investigation, salivary troponin I failed to demonstrate a meaningful correlation with serum troponins, thereby limiting its practical utility in diagnosing myocardial injury or myocardial infarction. Further research is warranted to explore its diagnostic reliability and clinical applicability.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1440138/fullsalivary troponinserum troponincorrelationmyocardial injurychest discomfort |
| spellingShingle | Hoa Tran Vu Hoang Vu Quang Dang Duy Pham Duc Minh Tran Suong Thi Bang Nguyen Vien Thanh Truong Binh Quang Truong Salivary cardiac troponin does not correlate with serum levels Frontiers in Cardiovascular Medicine salivary troponin serum troponin correlation myocardial injury chest discomfort |
| title | Salivary cardiac troponin does not correlate with serum levels |
| title_full | Salivary cardiac troponin does not correlate with serum levels |
| title_fullStr | Salivary cardiac troponin does not correlate with serum levels |
| title_full_unstemmed | Salivary cardiac troponin does not correlate with serum levels |
| title_short | Salivary cardiac troponin does not correlate with serum levels |
| title_sort | salivary cardiac troponin does not correlate with serum levels |
| topic | salivary troponin serum troponin correlation myocardial injury chest discomfort |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1440138/full |
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