Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women
Sensitive skin (SS) is associated with discomfort, including burning, stinging, and itching. These symptoms are often exacerbated by environmental factors and personal care products. In this genome-wide association study (GWAS), we aimed to identify the genetic variants associated with SS in 1690 Ko...
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2024-10-01
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| author | Seoyoung Kim Kyung-Won Hong Mihyun Oh Susun An Jieun Han Sodam Park Goun Kim Jae Youl Cho |
| author_facet | Seoyoung Kim Kyung-Won Hong Mihyun Oh Susun An Jieun Han Sodam Park Goun Kim Jae Youl Cho |
| author_sort | Seoyoung Kim |
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| description | Sensitive skin (SS) is associated with discomfort, including burning, stinging, and itching. These symptoms are often exacerbated by environmental factors and personal care products. In this genome-wide association study (GWAS), we aimed to identify the genetic variants associated with SS in 1690 Korean female participants; 389 and 1301 participants exhibited sensitive and non-sensitive skin, respectively. Using a combination of self-reported questionnaires, patch tests, and sting tests, we selected 115 sensitive and 181 non-sensitive participants for genetic analysis. A GWAS was performed to identify the loci associated with SS. Although none of the single-nucleotide polymorphisms (SNPs) met the genome-wide significance threshold, we identified several SNPs with suggestive associations. SNP rs11689992 in the 2q11.3 region increased SS risk by approximately 3.67 times. SNP rs7614738 in the <i>USP4</i> locus elevated SS risk by 2.34 times and was found to be an expression quantitative trait locus for <i>GPX1</i>, a gene involved in oxidative stress and inflammation. Additionally, SNPs rs12306124 in the <i>RASSF8</i> locus and rs10483893 in the <i>NRXN3</i> region were identified. These results suggest that the genetic variations affecting oxidative stress, cell growth regulation, and neurobiology potentially influence skin sensitivity, providing a basis for further investigation and the development of personalized approaches to manage sensitive skin. |
| format | Article |
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| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-10-01 |
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| spelling | doaj-art-8c375ee9af634b66a457169558f514262024-11-26T18:10:00ZengMDPI AGLife2075-17292024-10-011411135210.3390/life14111352Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean WomenSeoyoung Kim0Kyung-Won Hong1Mihyun Oh2Susun An3Jieun Han4Sodam Park5Goun Kim6Jae Youl Cho7Safety and Microbiology Laboratory, Amorepacific R&I Center, Yongin 17074, Republic of KoreaInstitute of Advanced Technology, Theragen Health Co., Ltd., Seongnam 13493, Republic of KoreaSafety and Microbiology Laboratory, Amorepacific R&I Center, Yongin 17074, Republic of KoreaSafety and Microbiology Laboratory, Amorepacific R&I Center, Yongin 17074, Republic of KoreaSafety and Microbiology Laboratory, Amorepacific R&I Center, Yongin 17074, Republic of KoreaSafety and Microbiology Laboratory, Amorepacific R&I Center, Yongin 17074, Republic of KoreaSafety and Microbiology Laboratory, Amorepacific R&I Center, Yongin 17074, Republic of KoreaDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of KoreaSensitive skin (SS) is associated with discomfort, including burning, stinging, and itching. These symptoms are often exacerbated by environmental factors and personal care products. In this genome-wide association study (GWAS), we aimed to identify the genetic variants associated with SS in 1690 Korean female participants; 389 and 1301 participants exhibited sensitive and non-sensitive skin, respectively. Using a combination of self-reported questionnaires, patch tests, and sting tests, we selected 115 sensitive and 181 non-sensitive participants for genetic analysis. A GWAS was performed to identify the loci associated with SS. Although none of the single-nucleotide polymorphisms (SNPs) met the genome-wide significance threshold, we identified several SNPs with suggestive associations. SNP rs11689992 in the 2q11.3 region increased SS risk by approximately 3.67 times. SNP rs7614738 in the <i>USP4</i> locus elevated SS risk by 2.34 times and was found to be an expression quantitative trait locus for <i>GPX1</i>, a gene involved in oxidative stress and inflammation. Additionally, SNPs rs12306124 in the <i>RASSF8</i> locus and rs10483893 in the <i>NRXN3</i> region were identified. These results suggest that the genetic variations affecting oxidative stress, cell growth regulation, and neurobiology potentially influence skin sensitivity, providing a basis for further investigation and the development of personalized approaches to manage sensitive skin.https://www.mdpi.com/2075-1729/14/11/1352sensitive skingenome-wide association studysingle-nucleotide polymorphism<i>RASSF8</i><i>GPX1</i> |
| spellingShingle | Seoyoung Kim Kyung-Won Hong Mihyun Oh Susun An Jieun Han Sodam Park Goun Kim Jae Youl Cho Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women Life sensitive skin genome-wide association study single-nucleotide polymorphism <i>RASSF8</i> <i>GPX1</i> |
| title | Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women |
| title_full | Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women |
| title_fullStr | Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women |
| title_full_unstemmed | Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women |
| title_short | Genetic Variants Associated with Sensitive Skin: A Genome-Wide Association Study in Korean Women |
| title_sort | genetic variants associated with sensitive skin a genome wide association study in korean women |
| topic | sensitive skin genome-wide association study single-nucleotide polymorphism <i>RASSF8</i> <i>GPX1</i> |
| url | https://www.mdpi.com/2075-1729/14/11/1352 |
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