Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation

Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation

Deficient Anterior pituitary with common Variable Immune Deficiency (DAVID) syndrome results from NFKB2 heterozygous mutations, causing adrenocorticotropic hormone deficiency (ACTHD) and primary hypogammaglobulinemia. While NFKB signaling plays a crucial role in the immune system, its connection to...

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Bibliographic Details
Main Authors: Thi Thom Mac, Teddy Fauquier, Nicolas Jullien, Pauline Romanet, Heather Etchevers, Anne Barlier, Frederic Castinetti, Thierry Brue
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
pituitary development
Organoids
corticotroph deficit
pituitary hormone deficits
ACTH deficiency
DAVID syndrome
Online Access:https://elifesciences.org/articles/90875
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