Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products
Summary: There have been increasing concerns about the great risks posed by petroleum products which contribute to the progression endothelial renal vasoconstriction and hypertension. This study aims to investigate the modulatory effects of Roasted cashew nut on rats induced with endothelial renal v...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268524001001 |
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| author | J.K. Akintunde A.O. Okunubi O.A. Dosumu A.T. Omidiran A.D. Folayan S.O. Salami |
| author_facet | J.K. Akintunde A.O. Okunubi O.A. Dosumu A.T. Omidiran A.D. Folayan S.O. Salami |
| author_sort | J.K. Akintunde |
| collection | DOAJ |
| description | Summary: There have been increasing concerns about the great risks posed by petroleum products which contribute to the progression endothelial renal vasoconstriction and hypertension. This study aims to investigate the modulatory effects of Roasted cashew nut on rats induced with endothelial renal vasoconstriction syndrome upon exposure to mixed fractionated petroleum products (MFPP). Seventy male albino rats were randomized into seven (n=10) groups. Group I (normal control) was given distilled water. Group II was administered with MFPP (20 %/day). Group III was administered with MFPP (20 %/day) + atenolol (50 mg/kg). Group IV was administered with MFPP (20 %/day) + 10 % roasted cashew nut (10 %RCN). Group V was administered with MFPP (20 %/day) + (20 %RCN). Group VI was treated with 10 %RCN while Group VII was treated with 20 %RCN. Data were analyzed using one-way analysis of variance (ANOVA) and Duncan's multiple range test with P<0.05 considered significant. Oral RCN intervention prohibited endothelial renal vasoconstriction syndrome and hypertension by down-regulating the pro-inflammatory cytokines including IL-10, TNF-α, HIF-1, MCP-1 and p53 with a concomitant inhibition of the activities of arginase, phosphodiesterase-51 (PDE-51) and angiotensin converting enzyme (ACE). Furthermore, endothelial renal vasoconstriction syndrome was pointedly abrogated by treatment with RCN as depicted by the reduced activities of the enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA), AChE and MAO-A with a subsequent upsurge in the level of NO while the histological derangements caused by MFPP were completely abated. This study thus authenticates the proposition that RCN may be a valuable therapy in ameliorating apoptosis, renal pro-inflammatory cytokines and enzymes of ATP-hydrolysis in endothelial renal vasoconstriction syndrome and hypertensive rat model on exposure to MFPP. |
| format | Article |
| id | doaj-art-8c17db5f4cab4623a07e8debbedae943 |
| institution | Kabale University |
| issn | 2667-2685 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-8c17db5f4cab4623a07e8debbedae9432024-12-13T11:07:18ZengElsevierClinical Nutrition Open Science2667-26852024-12-0158183205Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum productsJ.K. Akintunde0A.O. Okunubi1O.A. Dosumu2A.T. Omidiran3A.D. Folayan4S.O. Salami5Medical Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria; Corresponding author.Medical Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaMedical Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaDepartment of Food Science and Technology, Federal University of Agriculture, Abeokuta, NigeriaMedical Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaMedical Biochemistry and Molecular Toxicology Research Group, Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, NigeriaSummary: There have been increasing concerns about the great risks posed by petroleum products which contribute to the progression endothelial renal vasoconstriction and hypertension. This study aims to investigate the modulatory effects of Roasted cashew nut on rats induced with endothelial renal vasoconstriction syndrome upon exposure to mixed fractionated petroleum products (MFPP). Seventy male albino rats were randomized into seven (n=10) groups. Group I (normal control) was given distilled water. Group II was administered with MFPP (20 %/day). Group III was administered with MFPP (20 %/day) + atenolol (50 mg/kg). Group IV was administered with MFPP (20 %/day) + 10 % roasted cashew nut (10 %RCN). Group V was administered with MFPP (20 %/day) + (20 %RCN). Group VI was treated with 10 %RCN while Group VII was treated with 20 %RCN. Data were analyzed using one-way analysis of variance (ANOVA) and Duncan's multiple range test with P<0.05 considered significant. Oral RCN intervention prohibited endothelial renal vasoconstriction syndrome and hypertension by down-regulating the pro-inflammatory cytokines including IL-10, TNF-α, HIF-1, MCP-1 and p53 with a concomitant inhibition of the activities of arginase, phosphodiesterase-51 (PDE-51) and angiotensin converting enzyme (ACE). Furthermore, endothelial renal vasoconstriction syndrome was pointedly abrogated by treatment with RCN as depicted by the reduced activities of the enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA), AChE and MAO-A with a subsequent upsurge in the level of NO while the histological derangements caused by MFPP were completely abated. This study thus authenticates the proposition that RCN may be a valuable therapy in ameliorating apoptosis, renal pro-inflammatory cytokines and enzymes of ATP-hydrolysis in endothelial renal vasoconstriction syndrome and hypertensive rat model on exposure to MFPP.http://www.sciencedirect.com/science/article/pii/S2667268524001001Roasted-cashew-nutVasoconstrictionRenalEndothelialPetroleum productsRats |
| spellingShingle | J.K. Akintunde A.O. Okunubi O.A. Dosumu A.T. Omidiran A.D. Folayan S.O. Salami Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products Clinical Nutrition Open Science Roasted-cashew-nut Vasoconstriction Renal Endothelial Petroleum products Rats |
| title | Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products |
| title_full | Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products |
| title_fullStr | Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products |
| title_full_unstemmed | Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products |
| title_short | Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products |
| title_sort | intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed fractionated petroleum products |
| topic | Roasted-cashew-nut Vasoconstriction Renal Endothelial Petroleum products Rats |
| url | http://www.sciencedirect.com/science/article/pii/S2667268524001001 |
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