The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation?
Cardiovascular disease (CVD) is the leading cause of death worldwide with mortality rates in women currently exceeding those in men. To date, evidence is widely lacking for unique female determinants of CVD. However, strong associations with psychological stress, obesity or elevated inflammatory bio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2020.614345/full |
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| author | Catherine Gebhard Catherine Gebhard Susan Bengs Susan Bengs Achi Haider Achi Haider Michael Fiechter Michael Fiechter Michael Fiechter |
| author_facet | Catherine Gebhard Catherine Gebhard Susan Bengs Susan Bengs Achi Haider Achi Haider Michael Fiechter Michael Fiechter Michael Fiechter |
| author_sort | Catherine Gebhard |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of death worldwide with mortality rates in women currently exceeding those in men. To date, evidence is widely lacking for unique female determinants of CVD. However, strong associations with psychological stress, obesity or elevated inflammatory biomarkers with adverse cardiovascular outcomes in women have been identified in various studies. Interestingly, amygdalar metabolic activity, a central neural structure involved in emotional stress processing, has proven to be an independent predictor of major adverse cardiovascular events (MACE). Moreover, upregulated amygdalar metabolism was directly linked to myocardial injury in women, but not in men. This newly suggested sex-dependent brain-heart interrelation was further supported by the discovery that bone marrow activity, a surrogate parameter of inflammation, represents a potential bridging link between amygdalar activity and cardiovascular pathology by fueling inflammatory processes that promote atherosclerotic disease. Such malignant cascade of events might account, at least in part, for the excess female mortality seen in women with coronary artery disease and calls for sex-specific research toward pharmacologic or behavioral modulators to improve cardiovascular outcomes, particularly in women. This mini review summarizes recent advances in cardiovascular sex-specific medicine, thereby focusing on the interplay between the limbic system, autonomic regulation and inflammatory biomarkers, which may help to tailor CVD management toward the female cardiovascular phenotype. |
| format | Article |
| id | doaj-art-8bf78489b763463e9b9222dc86995929 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-8bf78489b763463e9b9222dc869959292025-01-07T15:21:32ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-12-011410.3389/fnins.2020.614345614345The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation?Catherine Gebhard0Catherine Gebhard1Susan Bengs2Susan Bengs3Achi Haider4Achi Haider5Michael Fiechter6Michael Fiechter7Michael Fiechter8Department of Nuclear Medicine, University Hospital Zurich, Zurich, SwitzerlandCenter for Molecular Cardiology, University of Zurich, Zurich, SwitzerlandDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, SwitzerlandCenter for Molecular Cardiology, University of Zurich, Zurich, SwitzerlandDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, SwitzerlandCenter for Molecular Cardiology, University of Zurich, Zurich, SwitzerlandDepartment of Nuclear Medicine, University Hospital Zurich, Zurich, SwitzerlandCenter for Molecular Cardiology, University of Zurich, Zurich, SwitzerlandSwiss Paraplegic Center, Nottwil, SwitzerlandCardiovascular disease (CVD) is the leading cause of death worldwide with mortality rates in women currently exceeding those in men. To date, evidence is widely lacking for unique female determinants of CVD. However, strong associations with psychological stress, obesity or elevated inflammatory biomarkers with adverse cardiovascular outcomes in women have been identified in various studies. Interestingly, amygdalar metabolic activity, a central neural structure involved in emotional stress processing, has proven to be an independent predictor of major adverse cardiovascular events (MACE). Moreover, upregulated amygdalar metabolism was directly linked to myocardial injury in women, but not in men. This newly suggested sex-dependent brain-heart interrelation was further supported by the discovery that bone marrow activity, a surrogate parameter of inflammation, represents a potential bridging link between amygdalar activity and cardiovascular pathology by fueling inflammatory processes that promote atherosclerotic disease. Such malignant cascade of events might account, at least in part, for the excess female mortality seen in women with coronary artery disease and calls for sex-specific research toward pharmacologic or behavioral modulators to improve cardiovascular outcomes, particularly in women. This mini review summarizes recent advances in cardiovascular sex-specific medicine, thereby focusing on the interplay between the limbic system, autonomic regulation and inflammatory biomarkers, which may help to tailor CVD management toward the female cardiovascular phenotype.https://www.frontiersin.org/articles/10.3389/fnins.2020.614345/fullcardiovascularautonomous nervous systeminflammationsexlimbic system |
| spellingShingle | Catherine Gebhard Catherine Gebhard Susan Bengs Susan Bengs Achi Haider Achi Haider Michael Fiechter Michael Fiechter Michael Fiechter The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? Frontiers in Neuroscience cardiovascular autonomous nervous system inflammation sex limbic system |
| title | The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? |
| title_full | The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? |
| title_fullStr | The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? |
| title_full_unstemmed | The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? |
| title_short | The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation? |
| title_sort | neuro inflammatory vascular circuit evidence for a sex dependent interrelation |
| topic | cardiovascular autonomous nervous system inflammation sex limbic system |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2020.614345/full |
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