Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation
Canine transmissible venereal tumor (TVT) is a naturally occurring, transmissible neoplasm primarily affecting the genitalia in dogs. Though generally benign, it can rarely metastasize to other body parts. This report describes a rare case of metastatic TVT in a 2-year-old female Boerboel, presentin...
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Universitas Airlangga
2025-01-01
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| Series: | Media Kedokteran Hewan |
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| Online Access: | https://e-journal.unair.ac.id/MKH/article/view/61554 |
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| author | Olanrewaju Samuel Olaifa Abdulrauf Adekunle Usman Taiwo Kemi Adebiyi Bamidele Nyemike Ogunro Adah Osereime Richard Edem Antia Favour Akinfemi Ajibade Ojuolape Adeyemi Adeshubomi Toluwalase Oluwatimilehin Soneye |
| author_facet | Olanrewaju Samuel Olaifa Abdulrauf Adekunle Usman Taiwo Kemi Adebiyi Bamidele Nyemike Ogunro Adah Osereime Richard Edem Antia Favour Akinfemi Ajibade Ojuolape Adeyemi Adeshubomi Toluwalase Oluwatimilehin Soneye |
| author_sort | Olanrewaju Samuel Olaifa |
| collection | DOAJ |
| description | Canine transmissible venereal tumor (TVT) is a naturally occurring, transmissible neoplasm primarily affecting the genitalia in dogs. Though generally benign, it can rarely metastasize to other body parts. This report describes a rare case of metastatic TVT in a 2-year-old female Boerboel, presenting with a large, ulcerated vulvar mass and metastases to the popliteal lymph node and mammary glands. Clinical findings included progressive mass growth, emaciation, and systemic symptoms. Hematological tests revealed non-regenerative anemia and elevated white blood cell count, while cytological examination identified neoplastic round cells with high nucleus-to-cytoplasm ratios and mitotic figures. The dog was treated with vincristine chemotherapy, metronidazole, vitamin C, and a diet supplemented with crude sap extract of Telfairia occidentalis at 120 mg/kg once daily. Significant tumor regression and clinical improvement were observed after four weeks, although persistent anemia and borderline hypoproteinemia were noted. By the fifth week, the mass had notably reduced, and the dog's condition continued to improve, though some hemorrhage remained. This case highlights the rare occurrence of metastatic TVT and underscores the effectiveness of vincristine in treatment, emphasizing the need for prompt diagnosis and management despite its generally low metastatic rate. |
| format | Article |
| id | doaj-art-8bf33e004f394a45b308de4ae35efdfc |
| institution | Kabale University |
| issn | 0215-8930 2775-975X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Media Kedokteran Hewan |
| spelling | doaj-art-8bf33e004f394a45b308de4ae35efdfc2025-01-10T11:23:48ZengUniversitas AirlanggaMedia Kedokteran Hewan0215-89302775-975X2025-01-01361778710.20473/mkh.v36i1.2025.77-8759721Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological EvaluationOlanrewaju Samuel Olaifa0Abdulrauf Adekunle Usman1https://orcid.org/0009-0007-6614-6343Taiwo Kemi Adebiyi2Bamidele Nyemike Ogunro3Adah Osereime4Richard Edem Antia5Favour Akinfemi Ajibade6Ojuolape Adeyemi Adeshubomi7Toluwalase Oluwatimilehin Soneye8University of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanUniversity of Ibadan, IbadanCanine transmissible venereal tumor (TVT) is a naturally occurring, transmissible neoplasm primarily affecting the genitalia in dogs. Though generally benign, it can rarely metastasize to other body parts. This report describes a rare case of metastatic TVT in a 2-year-old female Boerboel, presenting with a large, ulcerated vulvar mass and metastases to the popliteal lymph node and mammary glands. Clinical findings included progressive mass growth, emaciation, and systemic symptoms. Hematological tests revealed non-regenerative anemia and elevated white blood cell count, while cytological examination identified neoplastic round cells with high nucleus-to-cytoplasm ratios and mitotic figures. The dog was treated with vincristine chemotherapy, metronidazole, vitamin C, and a diet supplemented with crude sap extract of Telfairia occidentalis at 120 mg/kg once daily. Significant tumor regression and clinical improvement were observed after four weeks, although persistent anemia and borderline hypoproteinemia were noted. By the fifth week, the mass had notably reduced, and the dog's condition continued to improve, though some hemorrhage remained. This case highlights the rare occurrence of metastatic TVT and underscores the effectiveness of vincristine in treatment, emphasizing the need for prompt diagnosis and management despite its generally low metastatic rate.https://e-journal.unair.ac.id/MKH/article/view/61554canine tansmissible venereal tumour (tvt)cytologydoggenitalianeoplasm |
| spellingShingle | Olanrewaju Samuel Olaifa Abdulrauf Adekunle Usman Taiwo Kemi Adebiyi Bamidele Nyemike Ogunro Adah Osereime Richard Edem Antia Favour Akinfemi Ajibade Ojuolape Adeyemi Adeshubomi Toluwalase Oluwatimilehin Soneye Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation Media Kedokteran Hewan canine tansmissible venereal tumour (tvt) cytology dog genitalia neoplasm |
| title | Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation |
| title_full | Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation |
| title_fullStr | Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation |
| title_full_unstemmed | Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation |
| title_short | Case of Metastatic Canine Transmissible Venereal Tumor in a Dog: Clinical and Cytological Evaluation |
| title_sort | case of metastatic canine transmissible venereal tumor in a dog clinical and cytological evaluation |
| topic | canine tansmissible venereal tumour (tvt) cytology dog genitalia neoplasm |
| url | https://e-journal.unair.ac.id/MKH/article/view/61554 |
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