Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder
Background and objective: GATA3, an emerging immunohistochemical marker, is a zinc finger transcription factor that is expressed in normal urothelial epithelium and its corresponding neoplasms, and it has been recognized as a reliable urothelial related immunohistochemical marker. This study aimed t...
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| Language: | English |
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Hawler Medical University
2024-12-01
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| Series: | Zanco Journal of Medical Sciences |
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| Online Access: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/945 |
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| author | Shadan Abdulkhaliq Jaf Jalal Ali Jalal |
| author_facet | Shadan Abdulkhaliq Jaf Jalal Ali Jalal |
| author_sort | Shadan Abdulkhaliq Jaf |
| collection | DOAJ |
| description | Background and objective: GATA3, an emerging immunohistochemical marker, is a zinc finger transcription factor that is expressed in normal urothelial epithelium and its corresponding neoplasms, and it has been recognized as a reliable urothelial related immunohistochemical marker. This study aimed to detect the frequency of GATA3 expression in urothelial carcinoma of urinary bladder and determine its association with some clinicopathologic parameters.
Methods: Seventy-nine formalin fixed paraffin embedded blocks of urothelial carcinoma cases were randomly selected from a private laboratory in Erbil city during October 2019 to October 2021. In this study, GATA3, a Rabbit monoclonal antibody was applied on urothelial carcinoma cases and its expression was assessed.
Results: GATA3 was expressed in 94.9% of the study cases. It was expressed in all non-invasive and low-grade urothelial carcinoma cases and 97.1% of papillary urothelial carcinoma cases, while it down-expressed in high-grade, invasive and non-papillary urothelial carcinoma cases. A significant association was noted between GATA3 expression and tumor pattern (P = 0.034), while no significant association was noted between GATA3 expression and other clinicopathologic parameters like age, gender, tumor grade, lympho-vascular invasion and tumor stage.
Conclusion: GATA3 is a useful diagnostic immunohistochemical marker for urothelial carcinoma, as this marker was expressed in 94.9% of urothelial carcinoma cases with a significant association with tumor pattern. Further studies are required to evaluate GATA3 expression in association with urothelial cancer progression and metastasis. |
| format | Article |
| id | doaj-art-8bea3a381f4e4f57a49567df6f29ac58 |
| institution | Kabale University |
| issn | 1995-5588 1995-5596 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj-art-8bea3a381f4e4f57a49567df6f29ac582024-12-19T06:47:29ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962024-12-0128337738510.15218/zjms.2024.36Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladderShadan Abdulkhaliq Jaf0Jalal Ali Jalal1Department of Histopathology, Rizgary Teaching Hospital, Erbil, Iraq.Department of Basic Sciences/Pathology, College of Medicine, Hawler Medical University, Erbil, Iraq.Background and objective: GATA3, an emerging immunohistochemical marker, is a zinc finger transcription factor that is expressed in normal urothelial epithelium and its corresponding neoplasms, and it has been recognized as a reliable urothelial related immunohistochemical marker. This study aimed to detect the frequency of GATA3 expression in urothelial carcinoma of urinary bladder and determine its association with some clinicopathologic parameters. Methods: Seventy-nine formalin fixed paraffin embedded blocks of urothelial carcinoma cases were randomly selected from a private laboratory in Erbil city during October 2019 to October 2021. In this study, GATA3, a Rabbit monoclonal antibody was applied on urothelial carcinoma cases and its expression was assessed. Results: GATA3 was expressed in 94.9% of the study cases. It was expressed in all non-invasive and low-grade urothelial carcinoma cases and 97.1% of papillary urothelial carcinoma cases, while it down-expressed in high-grade, invasive and non-papillary urothelial carcinoma cases. A significant association was noted between GATA3 expression and tumor pattern (P = 0.034), while no significant association was noted between GATA3 expression and other clinicopathologic parameters like age, gender, tumor grade, lympho-vascular invasion and tumor stage. Conclusion: GATA3 is a useful diagnostic immunohistochemical marker for urothelial carcinoma, as this marker was expressed in 94.9% of urothelial carcinoma cases with a significant association with tumor pattern. Further studies are required to evaluate GATA3 expression in association with urothelial cancer progression and metastasis.https://zjms.hmu.edu.krd/index.php/zjms/article/view/945urothelial carcinomagata3immunohistochemistry |
| spellingShingle | Shadan Abdulkhaliq Jaf Jalal Ali Jalal Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder Zanco Journal of Medical Sciences urothelial carcinoma gata3 immunohistochemistry |
| title | Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder |
| title_full | Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder |
| title_fullStr | Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder |
| title_full_unstemmed | Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder |
| title_short | Immunohistochemical expression of GATA3 in urothelial carcinoma of urinary bladder |
| title_sort | immunohistochemical expression of gata3 in urothelial carcinoma of urinary bladder |
| topic | urothelial carcinoma gata3 immunohistochemistry |
| url | https://zjms.hmu.edu.krd/index.php/zjms/article/view/945 |
| work_keys_str_mv | AT shadanabdulkhaliqjaf immunohistochemicalexpressionofgata3inurothelialcarcinomaofurinarybladder AT jalalalijalal immunohistochemicalexpressionofgata3inurothelialcarcinomaofurinarybladder |