MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo

MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo

There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited. The intrinsic capacity of B cells to specifically activate tumour-specific CD4+ T cells in vivo via TCR-dependent interac...

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Bibliographic Details
Main Authors: Thomas V. Guy, Alexandra M. Terry, Helen M. McGuire, Elena Shklovskaya, Barbara Fazekas de St Groth
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Antigen presentation
B cell
MHC restriction
T cell
tumour
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2290799
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