Development of ptxD/Phi as a new dominant selection system for genetic manipulation in Cryptococcus neoformans

Development of ptxD/Phi as a new dominant selection system for genetic manipulation in Cryptococcus neoformans

ABSTRACT Cryptococcus neoformans is a globally distributed pathogenic fungus posing a significant threat to immunocompromised individuals, particularly those with HIV/AIDS. Effective genetic manipulation tools are essential for understanding its biology and developing new therapies. However, current...

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Bibliographic Details
Main Authors: Muthita Khongthongdam, Tanaporn Phetruen, Sittinan Chanarat
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:Microbiology Spectrum
Subjects:
Cryptococcus neoformans
genetic manipulation
gene deletion
selectable marker
ptxD gene
phosphite dehydrogenase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01618-24
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