Comprehensive RNA-seq analysis of benign prostatic hyperplasia (BPH) in rats exposed to testosterone and estradiol

Comprehensive RNA-seq analysis of benign prostatic hyperplasia (BPH) in rats exposed to testosterone and estradiol

Abstract The imbalance between estrogen and androgen may be an important mechanism of BPH, but the specific mechanism remains unclear. We used mixed sustained-release pellets made of testosterone and estradiol (T + E2) to stimulate the establishment of a BPH rat model. Compared to the prostate hyper...

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Bibliographic Details
Main Authors: Xiao-Hu Tang, Zhi-Yan Liu, Jing-Wen Ren, Heng Zhang, Ye Tian, Jian-Xin Hu, Zhao-Lin Sun, Guang-Heng Luo
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-87205-2
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