EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids

EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids

Abstract Concerning the structural analysis and optimization of various potential EGFR inhibitors. A series of heterocyclic compounds incorporating pyridine, 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole were successfully synthesized via a click reaction 12–21, resulting in high yields. The synt...

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Main Authors: Asma Khalaf Alshamari, Aljazi Abdullah AlRashidi, Faiza I. A. Abdella, Hissah Khashman Alshammari, Mona Zaheed Alshammari, Nuha Othman S. Alsaif, Tamer El Malah
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Journal of Saudi Chemical Society
Subjects:
EGFR
Cancer
1,3,4-oxadiazole
1,2,3-triazole
Apoptosis
Cell cycle arrest
Online Access:https://doi.org/10.1007/s44442-025-00004-2
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https://doi.org/10.1007/s44442-025-00004-2

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