A patient with probable rare blood Group B(A) phenotype
Karl Landsteiner discovered ABO blood group system in the early 20th century, but still, uncertainty remains in immunohematology while detection of ABO subgroups or weaker variants. The presence of weak subgroups in patient samples gives rise to the discrepancy in forward (cell) and reverse (serum)...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_166_21 |
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| author | Avineesh Chandra P. M. Bala Bhasker Romesh Jain Rakesh Kumar Subodh Srivastava |
| author_facet | Avineesh Chandra P. M. Bala Bhasker Romesh Jain Rakesh Kumar Subodh Srivastava |
| author_sort | Avineesh Chandra |
| collection | DOAJ |
| description | Karl Landsteiner discovered ABO blood group system in the early 20th century, but still, uncertainty remains in immunohematology while detection of ABO subgroups or weaker variants. The presence of weak subgroups in patient samples gives rise to the discrepancy in forward (cell) and reverse (serum) grouping. We here report a case of the B(A) phenotype in a patient who was diagnosed with chronic liver disease with acute pancreatitis, requiring packed red blood cells due to anemia. The blood group discrepancy was resolved using serological testing and adsorption–elution technique. Blood grouping by the tube technique showed 2+ agglutination with anti-A antisera, strong agglutination (4+) with anti-B, anti-AB, and anti-D antisera, 4+ agglutination with A1 cells, and no agglutination with B cells and O cells in serum grouping. Results for both eluate and last wash were negative to all the donor cells used. This report highlights the importance of cell and serum grouping, solving blood group discrepancy, and also in providing crossmatch compatible blood components without delay. This rare phenotype in a patient is the first of its kind reported from India. |
| format | Article |
| id | doaj-art-8bc576a6b3e24f8695f74a4a590fce32 |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-8bc576a6b3e24f8695f74a4a590fce322025-01-08T09:10:23ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652024-12-0118232032210.4103/ajts.ajts_166_21A patient with probable rare blood Group B(A) phenotypeAvineesh ChandraP. M. Bala BhaskerRomesh JainRakesh KumarSubodh SrivastavaKarl Landsteiner discovered ABO blood group system in the early 20th century, but still, uncertainty remains in immunohematology while detection of ABO subgroups or weaker variants. The presence of weak subgroups in patient samples gives rise to the discrepancy in forward (cell) and reverse (serum) grouping. We here report a case of the B(A) phenotype in a patient who was diagnosed with chronic liver disease with acute pancreatitis, requiring packed red blood cells due to anemia. The blood group discrepancy was resolved using serological testing and adsorption–elution technique. Blood grouping by the tube technique showed 2+ agglutination with anti-A antisera, strong agglutination (4+) with anti-B, anti-AB, and anti-D antisera, 4+ agglutination with A1 cells, and no agglutination with B cells and O cells in serum grouping. Results for both eluate and last wash were negative to all the donor cells used. This report highlights the importance of cell and serum grouping, solving blood group discrepancy, and also in providing crossmatch compatible blood components without delay. This rare phenotype in a patient is the first of its kind reported from India.https://journals.lww.com/10.4103/ajts.ajts_166_21abo subgroupsb(a) phenotypeblood group discrepancy |
| spellingShingle | Avineesh Chandra P. M. Bala Bhasker Romesh Jain Rakesh Kumar Subodh Srivastava A patient with probable rare blood Group B(A) phenotype Asian Journal of Transfusion Science abo subgroups b(a) phenotype blood group discrepancy |
| title | A patient with probable rare blood Group B(A) phenotype |
| title_full | A patient with probable rare blood Group B(A) phenotype |
| title_fullStr | A patient with probable rare blood Group B(A) phenotype |
| title_full_unstemmed | A patient with probable rare blood Group B(A) phenotype |
| title_short | A patient with probable rare blood Group B(A) phenotype |
| title_sort | patient with probable rare blood group b a phenotype |
| topic | abo subgroups b(a) phenotype blood group discrepancy |
| url | https://journals.lww.com/10.4103/ajts.ajts_166_21 |
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