SPP1+ TAM Regulates the Metastatic Colonization of CXCR4+ Metastasis‐Associated Tumor Cells by Remodeling the Lymph Node Microenvironment

SPP1+ TAM Regulates the Metastatic Colonization of CXCR4+ Metastasis‐Associated Tumor Cells by Remodeling the Lymph Node Microenvironment

Abstract Lymph node metastasis, the initial step in distant metastasis, represents a primary contributor to mortality in patients diagnosed with oral squamous cell carcinoma (OSCC). However, the underlying mechanisms of lymph node metastasis in OSCC remain incompletely understood. Here, the transcri...

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Bibliographic Details
Main Authors: Liang Dong, Shujun Hu, Xin Li, Shiyao Pei, Liping Jin, Lining Zhang, Xiang Chen, Anjie Min, Mingzhu Yin
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
lymph node metastatic microenvironment
macrophage
oral squamous cell carcinoma
single cell RNA sequencing
SPP1
Online Access:https://doi.org/10.1002/advs.202400524
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